临床医用1.5T磁共振对AD模型大鼠的颅脑MR成像研究  

To Investigate the Brain MRI Imaging of Model Rats with Alzheimer's Disease by Using 1.5 T Clinical Medical

作　　者：马伟琼[1] 谢琦[1,2] 陈明旺[1] 徐海侠[3] 张鼎旋 汤间仪[1] 

机构地区：[1]广州医科大学附属广州市第一人民医院医学影像部,广东广州510180 [2]广东省广州市南沙中心医院影像科,广东广州511457 [3]湖南省长沙市中心医院放射科,湖南长沙410004

出　　处：《中国CT和MRI杂志》2014年第6期1-3,25,共4页Chinese Journal of CT and MRI

基　　金：广东省科技计划项目;201 1B031800133;广州市医药卫生科技计划项目;20121 A011036

摘　　要：目的使用临床医用1.5TMR成像仪对阿尔茨海默病(Alzheimer Disease,AD)大鼠模型的颅脑行MR成像研究。材料和方法随机选择健康雌性SD大鼠10只(7-8周),通过多影响因素建立SD大鼠的AD模型,然后使用临床医用1.5TMR成像仪对AD模型大鼠进行T1WI、T2WI、T2*WI、SWI成像。结果 AD模型大鼠大脑的颞顶叶皮质、腹侧海马下皮质区和海马区可以发现一些散在的类圆形的低信号区,并与脑实质Aβ免疫组化、Thioflavine S及铁染色阳性结果相重叠。结论在未有超高场小动物专用磁共振成像仪的情况下,临床医用磁共振对AD模型大鼠颅脑MR成像的研究是可行的。Objective The 1.5T MR imager was used to investigate the MRI imaging of model rats＇ brain which with Alzheimer＇s disease.Methods Ten female SD rats, aged 7-8 weeks,were selected randomly. Then induced Alzheimer＇s disease model basing on multi-effects factors. Finally, the MRI sequences of T1WI、T2WI、T2＊WI and SWI were scanned by using 1.5T MR imager.Results Some round hypointensity focus can be detected in the cortex and hippocampus of the AD model rat brain,which appeared a overlap with the positive results of βimmunohistochemical staining、Thioflavin S staining and iron staining.Conclusion When the high field MRI imager which can be offered for animals exclusively are in the scarce case, the brain MR imaging of rat model with clinical medical 1.5T MR imager is feasible.

关 键 词：AD模型大鼠 临床医用磁共 振 T2 T2＊加权成像 磁敏感 加权成像 

分 类 号：R741[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]