度洛西汀与舍曲林治疗伴有焦虑症状的抑郁症患者疗效比较  

Comparison of efficacy of Duloxetine and Sertraline in treatment of depression with anxiety

作　　者：谢年秀[1] 谭文钟[1] 张莉[1] 杨力[1] 

机构地区：[1]江苏省常熟市第三人民医院,江苏常熟215500

出　　处：《中国民康医学》2014年第17期8-9,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨度洛西汀与舍曲林治疗伴有焦虑症状的抑郁症疗效和安全性。方法:78例符合入组标准的患者随机分成度洛西汀组和舍曲林组,各39例,治疗8周。患者于治疗前及治疗1、2、4、6、8周,应用汉密尔顿抑郁量表(HAMD-17)、汉密尔顿焦虑量表(HAMA)评定疗效,同时用治疗中出现的症状量表(TESS)评估安全性。结果:两组患者HAMD、HAMA总分均较治疗前显著下降(P<0.01);第1周度洛西汀组患者HAMD、HAMA总分下降显著比舍曲林组多(P<0.01),在其它几周差异无统计学意义(P均>0.05)。两组间不良反应发生率差异无统计学意义(P>0.05)。结论:度洛西汀与舍曲林治疗伴有焦虑症状的抑郁症疗效相当,但度洛西汀起效更快。Objective：To evaluate efficacy and safety of Duloxetine and Sertraline in treatment of depression with anxiety.Methods：78 patients with depression with anxiety randomly received Duloxetine （n=39） and Sertraline （n=39） for 8 weeks. Beforeand 1, 2, 4, 6 and 8 weeks after the treatment, Hamilton depression scale（HAMD-17） and Hamilton anxiety scale （HAMA） wereused to evaluate the efficacy; the adverse events were assessed by the treatment emergent symptom scale （TESS） 1,2,4,6 and 8 weeksafter the treatment,respectively. Results： The HAMD-17 and HAMA total scores were improved significantly for both groups after thetreatment （P〈0. 01）. At the end of the first week, the total scores of HAMD and HAMA in Duloxetine group were significant lowerthan those of the Sertraline group （P〈0. 01）; while there were no statistical differences in the total scores of HAMD and HAMA be-tween the two groups 2, 4, 6 and 8 weeks after the treatment. The incidences of the adverse reactions between the two groups showed nosignificant difference（P〉0. 05）. Conclusions： The efficacy on depression with anxiety is not different between Duloxetine and Sertra-line. However, Duloxetine has an earlier response than Sertraline.

关 键 词：抑郁症 焦虑 度洛西汀 舍曲林 

分 类 号：R749.41[医药卫生—神经病学与精神病学]