丙戊酸钠联合癫痫平序贯治疗癫痫的临床观察  

Clinical observation of sequential therapy of valproate combined with Dianxianping tablet in treating epilepsy

作　　者：李作吉 王春波[1] 隋忠国[1] 徐文[1] 孙桂臻 宿振宇 

机构地区：[1]青岛大学医学院,山东青岛266021 [2]山东省高密市人民医院,山东高密261500 [3]山东省高密市精神卫生中心,山东高密261500

出　　处：《中国医药科学》2014年第16期58-60,共3页China Medicine And Pharmacy

摘　　要：目的观察丙戊酸钠联合癫痫平序贯治疗癫痫的临床疗效,探讨其有效性及安全性,以期更有效地控制癫痫发作。方法 76例癫痫患者随机分为治疗组和对照组,治疗组在常规治疗基础上联合癫痫平的剂量调整,对照组为丙戊酸钠常规疗法。观测两组患者临床疗效、不良反应、治疗时间与发作频率的相互关系。结果治疗组(40例)有效控制发作,较对照组(36例)临床疗效显著提高,不良反应发生率降低;两组治疗后癫痫发作严重程度积分值比较,差异有统计学意义(P<0.05)。结论在抗癫痫治疗过程中,丙戊酸钠联合癫痫平序贯疗法,中西药作用机制协同、时间互补、效应增强,疗效优于单用丙戊酸钠。ObjectiveTo investigate the efficacy and safety of sequential therapy of valproate combined with Dianxianping tablet in treating epilepsy for more effective to control epilepsy.Methods76 patients with epilepsy were randomly divided into treatment group（40 cases） and control group （36 cases）. The treatment group was given the treatment of sequential therapy of valproate combined with Dianxianping tablet,and the patients of control group were given the treatment of valproate. Clinical curative effect, adverse reactions, treatment time and seizure frequency relationships of two groups were observed. ResultsThe treatment group could effectively control the seizures. The clinical efficacy of treatment group was better than that of control group, and the adverse reaction of the observation group was lower than that in the control group. After treatment, the difference of two groups seizure severity score was statistically significant （P〈0.05）.ConclusionIn the treatment of epilepsy, valproate combined with Dianxianping tablet can make synergistic effect of traditional Chinese medicine and Western medicine, complementary time, and enhancement effect. Its curative effect is better than single valproate.

关 键 词：癫痫 丙戊酸钠 癫痫平 序贯疗法 疗效观察 

分 类 号：R742.1[医药卫生—神经病学与精神病学]