硅烷化修饰的固态纳米孔  

Solid Nanopores Modified with Silanes

作　　者：武灵芝[1] 刘伟[1] 赵启前 陈豪[1] 刘玉棋 

机构地区：[1]南京邮电大学地理与生物信息学院,南京210046

出　　处：《生物物理学报》2014年第4期300-308,248,共9页Acta Biophysica Sinica

基　　金：国家自然科学基金青年项目(61101056);南京邮电大学校科研基金项目(NY213185);实验室研究课题(17032SG1310);中国博士后科学基金(20110491339)~~

摘　　要：作为一种重要的单分子检测技术,纳米孔的表面特性至关重要。作者利用聚焦离子束刻蚀方法制备得到了一系列形貌可控的氮化硅纳米孔,并对纳米孔进行了表面改性修饰。结果发现,经过化学处理的氮化硅表面具有大量的硅羟键,非常利于和硅烷发生反应,从而在纳米孔表面引入活性基团,如氨基、正辛基和巯基等。通过对修饰有不同硅烷的纳米孔的表面特性和电导特性的研究发现,当硅烷分子将氮化硅表面的硅羟键变为其它功能基团时,材料表面电荷会发生变化,亲、疏水性也发生变化,从而导致电渗流的改变,影响纳米孔的电导。同时,修饰硅烷分子后,材料表面的电荷特性发生了改变,也会导致纳米孔器件的膜电容减小,介电噪声降低。As an important single molecule technology, the surface property of nanopores is a crucial factor. A set of nanopores with varied diameters and shapes have been fabricated by focused ion beam, then modified with silanes. The cleaning surface of silicon membrane contained substantial silanol groups, which were easily reacted with silanes coating with functional groups （amine, n-octyl and sulfydryl）. Based on the measurements of surface behavior and ionic current of modified nanopores, it was found that the hydrophilic properties of nanopores decreased in the presence of functional silane monolayers, and the conductance changed owing to the electroosmotic flow. Meanwhile, the noise power spectra showed that the dielectric noise was improved together with the reduction of membrane capacitance of nanopore devices.

关 键 词：纳米孔 氮化硅 硅烷化修饰 电导 

分 类 号：O64[理学—物理化学]