中青年无症状脑梗死患者血清高敏C-反应蛋白、同型半胱氨酸、尿酸水平与颈动脉内-中膜厚度的关系  

Relationship between the level of serum high sensitivity C- reactive protein,homocysteine,urine acid and the degree of carotid intima-media thickness in young and middle-aged patients with silent cerebral infarction

作　　者：张艳茹[1] 张丽敏[1] 曹向辉 王红梅[1] 贺永贵[1] 

机构地区：[1]河北联合大学附属医院神经内一科,唐山063000 [2]冀中能源峰峰集团邯郸医院骨二科

出　　处：《临床神经病学杂志》2014年第4期265-267,共3页Journal of Clinical Neurology

摘　　要：目的探讨中青年无症状脑梗死(SCI)患者血清高敏C-反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)、尿酸水平与颈动脉内-中膜厚度(IMT)的关系。方法检测96例中青年SCI患者(SCI组)及100名正常对照者(正常对照组)的血hs-CRP、Hcy、尿酸水平。患者均行颈动脉彩色多普勒超声检查,根据IMT将SCI组分为内膜正常亚组、内膜增厚亚组、稳定斑块亚组及不稳定斑块亚组。结果 SCI组血清hs-CRP、Hcy、尿酸水平及IMT均显著高于正常对照组(均P<0.001)。将SCI组患者分为内膜正常亚组16例,内膜增厚亚组34例,稳定斑块亚组28例,不稳定斑块亚组18例。与内膜正常亚组比较,内膜增厚、稳定斑块及不稳定斑块亚组的血hs-CRP、Hcy和尿酸水平显著增高(均P<0.01)。不稳定斑块亚组的血hs-CRP、Hcy和尿酸水平显著高于内膜增厚亚组及稳定斑块亚组(均P<0.01)。Pearson相关性分析显示,SCI组颈动脉IMT与血hs-CRP、Hcy、尿酸水平呈正相关(r=0.891,r=0.757,r=0.531;均P<0.01)。结论血清hs-CRP、Hcy、尿酸水平与中青年患者颈动脉粥样硬化及其严重程度紧密相关。Objective To investigate the relationship between the level of serum high-sensitivity C-reactive protein （hs-CRP）, Homoeysteine （Hey）, Uric acid （UA） and the degree of carotid intima-media thickness （IMT） in young and middle-aged patients with silent cerebral infarction （SCI）. Methods Detected the level of serum hs- CRP, Hcy and UA in 96 young and middle-aged patients with SCI （SCI group） and 100 normal controls （normal control group）. All patients were performed the carotid artery by the Doppler ultrasonography. SCI group was divided into carotid intima normal subgroup, intima thickening subgroup, stable plaque subgroup and unstable plaque subgroup based on the degree of IMT. Results Levels of serum hs-CRP, Hcy, UA and the degree of IMT in SCI group were significantly higher than those in normal control group （ all P 〈 0. 001 ）. SCI patients were divided into intima normal subgroup （ 16 eases） , intima thickening subgroup （34 cases） , stable plaque subgroup （28 cases） and unstable plaque subgroup（18 cases） Compared with carotid intima normal subgroup, levels of serum hs-CRP, Hcy and UA were significantly increased in intimal thickening subgroup, stable plaques subgroup and unstable plaques subgroup （ all P 〈 0. 01 ）. Levels of serum hs-CRP, Hcy and UA in unstable plaque subgroup were significantly higher than those of intimal thickening subgroup and stable plaque subgroup （ all P 〈 0.01 ）. Pearson correlation analysis showed that the degree of IMT was positively correlated with the level of serum hs-CRP, Hcy, and UA in SCI group. （r=0.891, r=0.757, r=0.531; allP〈O. O1）.Conclusion The level of serum hs-CRP, Hcy, UAare closely associated with young and middle-aged SCI patients carotid atheroselerosis and serious extent.

关 键 词：无症状性脑梗死 高敏C反应蛋白 同型半胱氨酸 尿酸 颈动脉内-中膜厚度 

分 类 号：R743.3[医药卫生—神经病学与精神病学]