白血病干细胞及其靶向清除  

Leukemia Stem Cells and Their Targeted Clearance——Review

作　　者：刘博[1] 史策[1] 周晋[1] 

机构地区：[1]哈尔滨医科大学附属第一医院血液科,黑龙江哈尔滨150001

出　　处：《中国实验血液学杂志》2014年第4期1120-1123,共4页Journal of Experimental Hematology

基　　金：国家青年科学基金(81200357)

摘　　要：白血病干细胞是引起白血病的根源,也是其易于复发的主要原因。研究者希望通过一些手段能够特异性的标记出白血病干细胞并将其靶向清除,进而推动白血病的治疗进展。本文详细介绍了白血病干细胞自身特性及其所处微环境的特征,系统性的回顾了目前国际上公认的特异性标记白血病干细胞的几种主要途径和方法,包括标记白血病干细胞自我更新及凋亡的信号通路,标记白血病干细胞的细胞周期及其所处微环境相关的信号通路以及标记白血病干细胞的特异性免疫表型。通过这些标记手段或许可以彻底的清除白血病干细胞,消灭微小残留病灶。但是目前,没有哪一种特异性的方法可以独立清除白血病干细胞,或许联合标记白血病干细胞的免疫表型和阻断其所处的微环境信号通路可以靶向清除白血病干细胞,改善白血病的预后。Leukemia stem cells （LSC） are the root causes of the leukemia, and are also the main reason for the leu- kemia relapse. Researchers hope that there are some methods to specifically mark the LSC and to clear them for promoting the advancements in the treatment of leukemia. This review discusses the biological characteristics of LSC and its microenvironment, the current internationally recognized main methods for specific marking of LSC, including marking LSC self-renewal, apoptosis signaling pathways, microenvironment, cell cycle-related signaling pathways and LSC-spe- cific immune phenotype, so as to eliminate LSC and minimal residual disease through these marking ways. But, at pres- ent, there are no specific methods to remove leukaemia stem cells independently, possibly the combination of LSC immune phenotype with blocking the microenvironment signaling pathways can target at and remove LSC, thus improving the prognosis of leukemia.

关 键 词：白血病 白血病干细胞 靶向清除 

分 类 号：R733.7[医药卫生—肿瘤] R329.28[医药卫生—临床医学]