Notch-1信号通路在肿瘤中的研究进展  

Recent progress of Notch-1 signaling pathway in tumor research

作　　者：张庆庆[1] 陈伟 张森林[1] 

机构地区：[1]南方医科大学南京临床医学院(南京军区南京总医院)口腔科,南京医学硕士研究生210002

出　　处：《医学研究生学报》2014年第8期871-873,共3页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81102051);江苏省自然科学基金(BK2011659)

摘　　要：Notch-1是Notch基因家族的成员之一,Notch-1信号通路在细胞的增殖、分化、生存和凋亡中起着重要作用,其异常表达与肿瘤的发生、发展密切相关。近年来,Notch-1信号通路和肿瘤的关系研究颇多。文中就该信号通路在肿瘤中的研究进展作一综述。As one of members of the Notch gene family, Notch-1 signaling pathway plays an important role in the processing of cell proliferation, differentiation, survival and apoptosis. The abnormal expression of Notch-1 is closely related to tumorigenesis and development. In recent years, many studies have focused on the relationship between the Notch-1 signaling pathway and tumor. This article reviews the achievement of Notch-1 signaling pathway in recent tumor researches.

关 键 词：NOTCH-1 肿瘤 信号通路 

分 类 号：R73[医药卫生—肿瘤]