乳腺神经内分泌癌的超声表现及病理特点  

Ultrasonographic and histopathological characteristics of breast neuroendocrine carcinoma

作　　者：虞晓龙[1] 金梓涵 李尊[1] 郑建刚[3] 奚静[1] 周喜[1] 王珏[1] 

机构地区：[1]江苏大学附属武进医院超声科,江苏省常州市213200 [2]南京医科大学附属常州第二人民医院检验科 [3]江苏大学附属武进医院放射科,江苏省常州市213200

出　　处：《临床超声医学杂志》2014年第8期558-560,共3页Journal of Clinical Ultrasound in Medicine

摘　　要：目的探讨乳腺神经内分泌癌的超声表现及病理特点。方法分析4例乳腺神经内分泌癌患者的临床资料、超声表现、病理及免疫组化结果。结果乳腺肿块2例位于右侧,2例位于左侧;4例均为不均匀低回声,2例表现为斑点状钙化,3例血流信号丰富。免疫组化检查,均表达嗜铬颗粒蛋白A(CgA)、神经元特异性烯醇化酶(NSE),3例表达突触素(Syn)。随访期间未见复发。结论乳腺神经内分泌癌是一种罕见的乳腺恶性肿瘤,超声表现有一定特征,雌孕激素受体阳性与CerbB-2基因表达阴性是预后良好的指标,确诊主要依靠病理组织学检查及免疫组化染色。Objective To investigate the ultrasonographic features of breast neuroendocrine carcinoma as well as its clinical and histopathological characteristics. Methods The clinical data,ultrasonographic features,pathological and immunohistochemical results of four patients with breast neuroendocrine cancer were analyzed. Results The masses of 2 patients located in the right breast,the other two were in the left side. Among all the 4 cases,masses showed uneven low echo,2 of them presented punctate calcification,3 showed rich blood flow. Results In histopathological examination,the CgA and NSE were expressed in all cases and Syn was expressed in 3 cases. During the follow-up period,no recurrence was found. Conclusion Breast neuroendocrine carcinoma is a kind of rare breast malignancy. It has a certain ultrasonographic features. The positive estrogen and progesterone receptor and CerbB-2 gene expression are indicators for the good prognosis. The diagnosis of breast neuroendocrine carcinoma mainly relies on histopathological examination and immunohistochemical staining.

关 键 词：超声检查 免疫组织化学 神经内分泌癌 乳腺 

分 类 号：R737.9[医药卫生—肿瘤] R445.1[医药卫生—临床医学]