牙周炎伴COPD患者血清25-(OH)D、TNF-α和IL-6水平检测的研究  

Clinical Significance of Serum Levels of 25-(OH)D,TNF-α and IL-6 in Patients with Periodontal Disease and Chronic Obstructive Pulmonary Disease

作　　者：韩静[1] 李威[1] 李一梓[1] 王左敏[1] 

机构地区：[1]首都医科大学附属北京朝阳医院口腔科,北京100020

出　　处：《口腔医学研究》2014年第8期743-746,共4页Journal of Oral Science Research

基　　金：国家自然科学基金资助项目(编号:81000449)

摘　　要：目的:探讨慢性牙周炎与慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者的血清25-(OH)D、TNF-α和IL-6水平变化及相互关系。方法:收集符合条件的COPD伴牙周炎患者[(C+P)组]20例,单纯慢性牙周炎患者(P组)20例,同期门诊随诊的健康对照组(H组)20例。采集临床指标并采用ELISA法检测3组受试者血清25-(OH)D、TNF-α和IL-6的含量。结果:各组间牙周病指数有显著性差异。(C+P)组与P组、H组相比,TNF-α和IL-6水平明显升高,差别有统计学意义(P<0.05);25-(OH)D水平较低,但差别无统计学意义。等级相关性分析结果显示H组血清25-(OH)D与IL-6呈负性相关关系(P<0.05),C+P组血清25-(OH)D与Tnf-α呈负性相关关系(P<0.05)。结论:25-(OH)D、TNF-α和IL-6可能与牙周炎和COPD病理机制相关,牙周炎和COPD之间存在一定的关联。Objective： To explore the possible relationship of serum levels of 25-（OH）D, TNF-α and IL-6 in patients with chronic obstructive pulmonary disease（COPD） and periodontal disease（CP）. Methods： A total of 60 subjects were included in this study. Among them, 20 were patients with COPD and CP （group C＋P）, 20 were patients with CP （group P） ,and 20 were healthy volunteers （group H）. The periodontal indexes and the serum levels of 25-（OH）D, TNF-α and IL-6 were measured. Results： The periodontal indexes including sulcus bleeding index, probing index and attachment loss were significantly different among the three groups. In group C＋P, the TNF-α and IL-6 levels were significantly higher in comparison to the other two groups（P〈0.05）. The results of Spearman correlation analysis showed that the levels of TNF-α and IL-6 in serum were negatively associated with that of 25-（OH）D in C＋P group and H group separately（P〈0.05）. Conclusion： 25-（OH）D ,TNF-α and IL- 6 might be closely related with the pathogenesis of COPD and chronic periodontitis. A certain correlation might ex-ist between COPD and chronic periodontiits.

关 键 词：慢性牙周炎 慢性阻塞性肺疾病 25-(OH)D TNF-Α IL-6 

分 类 号：R781.4[医药卫生—口腔医学]