鼻腔-鼻窦鳞状细胞癌中PDCD5和Bcl-2蛋白的表达及意义  

The expression and significance of programmed cell death 5 and bcelllymphoma/lewkmia-2 in sinonasal squamous cell carcinoma

作　　者：陆鸿略[1] 王成硕[2] 郝玲玲 尹桂茹[1] 郝然[1] 

机构地区：[1]承德医学院附属医院耳鼻咽喉科,河北承德067000 [2]首都医科大学附属同仁医院耳鼻咽喉头颈外科 [3]宽城县医院耳鼻咽喉科

出　　处：《临床耳鼻咽喉头颈外科杂志》2014年第17期1301-1304,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:研究程序性细胞死亡因子5(PDCD5)及Bcl-2蛋白在鼻腔、鼻窦鳞状细胞癌(SNSCC)中的表达及临床意义。方法:采用免疫组织化学SP法及Western blot技术分别检测46例SNSCC组织(SNSCC组),38例鼻腔、鼻窦内翻性乳头状瘤组织(SNIP组)中以及20例正常鼻腔黏膜(正常组)中PDCD5和Bcl-2蛋白的表达情况。结果:1与SNIP组及正常组相比,SNSCC组中PDCD5蛋白的表达明显下调,Bcl-2蛋白的表达明显上调;2在SNSCC组中,PDCD5蛋白及Bcl-2蛋白在高、中分化与低分化组中的阳性表达率分别是100.00%、83.33%、38.89%以及50.00%、70.83%、100.00%,组间均差异有统计学意义(均P<0.05)。4随访病例中,随着PDCD5表达的增强,患者生存评分呈增高趋势(P<0.05);而随着Bcl-2表达的减弱,患者生存评分增高(P<0.05)。结论:PDCD5蛋白的失活和Bcl-2蛋白的诱导可能与SNSCC的发生、发展密切相关,PDCD5有望为SNSCC的诊疗提供新的靶点。Objective：To explore the expression and significance of programmed cell death 5（PDCD5） and Bcelllym- phoma/lewkmia-2（Bcl-2） in sinonasal squamous cell carcinoma （SNSCC）. Method.. Immunohistochemical method and Western Blot method was used to determine the expression of PDCD5 and Bcl-2 in specimen of SNSCC in thirty cases , sinonasal inverted papillomas （ SNIP ） in thirty-eight cases, and normal nasal mucosa in twenty cases. Result：（1）The expression of PDCD5 protein in SNSCC significantly decreased compared with SNIP and normal nasal mucosa. （2）The expression of Bcl-2 protein in SNSCC up-regulated obviously compared with SNIP and normal nasal mucosa. （3）Positive rate of PDCD5 protein and Bcl-2 protein in well, moderate and low differentiatied group is respectively 100. 00%, 83.33 %, 38. 89% and 50. 00% ,70. 83% and 100.00% ,the difference was statistically significant （P〈0. 05）. OIn the follow-up cases, the survival rate of the patients with higher expression of PDCD5 protein was higher, but that with lower expression of Bcl-2 protein was higher. Conclusion.. The inactivation of PDCD5 protein and the activation of Bcl-2 protein may play an important role in the development of SNSCC, and there are a positive correlation between PDCD5 and Bcl-2 protein in SNSCC,which may be identified as a new therapeutic target.

关 键 词：鳞状细胞癌 程序性细胞死亡因子5 BCL-2 

分 类 号：R739.6[医药卫生—肿瘤]