人类肿瘤病毒介导缺氧信号致病机制的研究进展  

Advances in the pathogenesis of hypoxia signaling mediated by human oncogenic viruses

作　　者：张黎明[1] 朱彩霞[1] 蔡启良[1] 

机构地区：[1]复旦大学基础医学院教育部/卫生部医学分子病毒学重点实验室,上海200032

出　　处：《微生物与感染》2014年第3期131-138,共8页Journal of Microbes and Infections

基　　金：国家自然科学基金(30901758);国家重点基础研究发展计划(2012CB51901);上海市教委科研创新重点项目(12zz011);教育部新世纪优秀人才计划(NCET-13-0168)

摘　　要：病毒感染与多种肿瘤的发生发展密切相关,病毒入侵宿主细胞后常引发多个关键细胞信号通路的调控紊乱,其中对缺氧信号的调控尤为重要,日益受到关注。本文主要介绍各种常见人类肿瘤病毒如何通过编码毒蛋白篡改缺氧诱导因子(HIF)信号通路,以及在应答缺氧微环境时如何诱发肿瘤发生发展分子机制的研究进展,并概括肿瘤病毒介导HIF信号通路及其对缺氧应激反应的共有模式,提示肿瘤病毒调控缺氧信号诱发癌症的潜在治疗靶点和策略。It has been demonstrated that virus infection is closely associated with development of many types of tumors, and a number of cellular signaling pathways are often deregulated by oncogenic viruses after the invasion of host cells. Among them, deregulation of hypoxia signaling by oncogenic viruses is particularly important and has been greatly concerned. In this paper, we mainly address how a variety of oncoproteins encoded by common human oncogenic viruses tamper hypoxia-inducible factor （HIF） signaling pathway, and how viruses respond in hypoxic microenvironment in term of tumor development, as well as summarize a model of oncogenic virus-mediated HIF signaling pathways and response to hypoxic stress, which shed light on potential therapeutic targets and strategies against virus-associated cancers by interrupting hypoxia signaling.

关 键 词：缺氧信号 肿瘤病毒 致病 

分 类 号：R730.2[医药卫生—肿瘤]