多发性骨髓瘤相关微小RNA的研究进展  

Research progress of multiple myeloma related microRNA

作　　者：肖翠容[1] 鹿全意[2] 

机构地区：[1]福建医科大学协和临床医学院,福州350001 [2]厦门大学附属中山医院血液科

出　　处：《白血病．淋巴瘤》2014年第7期442-445,共4页Journal of Leukemia & Lymphoma

基　　金：国家自然科学基金（81172246）

摘　　要：微小RNA（miRNA）是一类非编码的小分子RNA,其可通过抑制特异靶基因的翻译或直接降解靶基因,实现基因的转录后调控.大量研究显示,miRNA的异常表达与多系统肿瘤相关,对多发性骨髓瘤（MM）的研究发现,miRNA的异常表达参与了MM细胞的增殖、分化、凋亡及耐药等过程,并可作为MM的诊断标志物;某些miRNA甚至可能作为MM的有效治疗靶点.文章就MM相关miRNA的异常表达与MM的诊断、发病机制、耐药形成及其作为治疗靶点潜力的研究进展进行综述.microRNA （miRNA） is a kind of non-coding small RNA that regulate gene expression at a post-transcriptional level by inhibiting the translation or direct degradation of specific target mRNA. Lots of studies have shown that deregulation of miRNA expression is associated with multisystem tumor. Studies on multiple myeloma （MM） have found that aberrant expression of miRNA regulate MM-cellular processes including cell proliferation, differentiation, apoptosis and drug-resistance. And they can act as diagnostic marker for MM. Some of the miRNA may even function as effective therapeutic targets. This paper reviewed the research progress of the aberrant expression of MM related miRNA in the diagnosis, pathogenesis, drug resistance of MM and its potential application as therapeutic targets.

关 键 词：多发性骨髓瘤 微小RNA 

分 类 号：R733.3[医药卫生—肿瘤]