COVDP方案治疗成人急性淋巴细胞白血病疗效分析  

Analysis on the Effect of COVDP for Treatment in Adult Acute Lymphoblastic Leukemia

作　　者：张晓敏[1] 董秀帅[1] 刘娟[1] 陈曦[1] 王京华[1] 

机构地区：[1]哈尔滨医科大学附属第二医院血液内科,黑龙江哈尔滨150086

出　　处：《现代生物医学进展》2014年第28期5476-5478,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨不同诱导方案治疗成人急性淋巴细胞自血病的疗效及合并症情况。方法:采用COVDP及DVLP诱导治疗方案将我科(2005-2011年)62例急性淋巴细胞白血病患者分为两组,A组采用COVDP诱导方案,B组采用DVLP诱导方案。比较两种不同诱导方案治疗成人急性淋巴细胞白血病的初治缓解率、感染率、是否延迟化疗及骨髓抑制时间。结果:两组方案骨髓缓解率差异无统计学意义(P>0.05),巩固治疗期间感染率差异有统计学意义(P<0.05),A组骨髓抑制时间为(15.51±0.82d)长于B组(9.63±0.71 d)(P<0.05),A组化疗延迟率为44.5%,高于B组(23.1%)(P<0.05)。结论:与COVDP诱导方案相比,DVLP诱导方案缩短了骨髓造血恢复时间,降低了感染率及化疗合并症的发生。Objective： To explore the curative effect and complcations of different induction programme in adult acute lymphoblastic leukemia. Methods： 62 acute lymphoblastic leukemia patients （2005-2011） were divided into two groups. Group A received COVDP plan, and group B received DVLP plan. The initial remission rate, the infection rate, whether or not to delay chemotherapy and the bone marrow suppression time were studied between the two groups. Results： The initial remission rates were not significant between the two groups （P〉0.05）. The infection rates were significant during consolidation therapy （P〈0.05）. The bone marrow suppression time in group A （15.51±0.82d） was longer than that in group B （9.63± 0.71d）. The delay rate of chemotherapy was higher in group A （44.5 %） was longer than that in group B （23.1%） （P〈0.05）. Conclusion： Compared to the plan of COVDP, the plan of DVLP shortened the bone marrow recovery time and reduced the rates of infection and complications.

关 键 词：急性淋巴细胞白血病 诱导缓解 化疗 成人 

分 类 号：R733.7[医药卫生—肿瘤]