EMT标志分子Vimentin在胃癌中的表达和临床意义  

Expression of Vimentin and Its Clinical Significance in Human Gastric Cancer

作　　者：张永国[1] 邵晓冬[1] 王红红 李宏宇[1] 郭晓钟[1] 

机构地区：[1]沈阳军区总医院消化内科,辽宁沈阳110016 [2]解放军518医院内科,陕西西安710043

出　　处：《现代生物医学进展》2014年第28期5479-5482,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81101891)

摘　　要：目的:探讨EMT标志分子Vimentin在胃癌中的表达和临床意义。方法:利用免疫组化染色的方法检测Vimentin在120例胃癌及其相应癌旁组织中的表达,统计分析Vimentin的表达水平与年龄、性别、组织学类型、TNM分期、淋巴结转移等临床病理特征间的相关性。结果:Vimentin在胃癌中的表达阳性率为55.8%,远高于相应癌旁组织的22.5%(P<0.01),进一步分析研究发现Vimentin的表达水平在Ⅲ和Ⅳ期的胃癌中(TNM分期)的表达明显高于Ⅰ和Ⅱ期的胃癌,差异具有统计学意义(P=0.009),在发生淋巴结转移胃癌中表达明显高于未发生淋巴结转移的胃癌,差异具有统计学意义(P<0.000)。结论:Vimentin在胃癌中高表达,其表达水平与TNM分期、淋巴结转移密切相关,提示Vimentin在胃癌的转移过程中可能发挥重要作用。Objective： To investigate the expression of Vimentin in gastric cancer and analyze the relationship between Vimentin expression and clinicopathologic features. Methods： IHC was performed to detect the expression of Vimentin in 120 cases of gastric cancer and the corresponding adjacent non-tumor tissues. The correlation between Vimentin expression and clinicopathologic features were analyzed. Results： Vimentin was detected in 22.5% of the adjacent non-tumor tissues. However, a high positive staining was identified in 55.8 % of the gastric cancer tissues. Further analysis showed there was higher expression level of Vimentin in Ⅲ and Ⅳstages gastric cancer or with lymph node metastasis than that in Ⅰ and Ⅱstages or without lymph node metastasis, but there was no difference between Vimentin expression and sex, age, or histologic grade. Conclusion： Vimentin over-expressed in gastric cancer. The expression level of Vimentin is correlated with TNM stage and lymph node metastasis. These findings indicate that Vimentin may play an important role in the gastric cancer metastasis.

关 键 词：VIMENTIN 胃癌 转移 

分 类 号：R573[医药卫生—消化系统]