干扰素联合利巴韦林治疗慢性丙型肝炎的疗效及对肝功能和肝纤维化指标的影响  

Clinical Effect of Interferon Combined with Ribavirin in Treating Chronic Hepatitis C and its Effect on Liver Function and Liver Fibrosis Indexes

作　　者：全昕[1] 牛越[2] 刘瑞峰[1] 孙明丽[1] 郭晓东[3] 

机构地区：[1]内蒙古巴彦淖尔市医院感染科,内蒙古巴彦淖尔015000 [2]内蒙古巴彦淖尔市医院肿瘤内科,内蒙古巴彦淖尔015000 [3]解放军302医院,北京100039

出　　处：《现代生物医学进展》2014年第28期5548-5551,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金青年科学基金项目(30901795)

摘　　要：目的:探讨干扰素联合利巴韦林治疗慢性丙型肝炎(Chronic Hepatitis C,CHC)的临床疗效以及对肝功能和肝纤维化指标的影响。方法:收集我院2011年3月至2012年3月收治的88例CHC患者,随机平均分为两组,对照组单用干扰素,观察组采用干扰素联合利巴韦林治疗,比较两组治疗后的临床疗效以及治疗前后肝功能和肝纤维化指标变化情况。结果:观察组治疗总有效率为90.91%,明显高于对照组的68.18%,两组比较差异具有统计学意义(P<0.05);观察组治疗后ALT和AST分别为(70.24±7.94)和(79.45±9.72),HA、PCⅢ、CⅣ和LN分别为(76.87±10.32)、(79.45±9.72)、(79.76±8.00)和(118.41±16.97),均明显高于治疗前和对照组,差异具有统计学意义(P<0.05)。结论:干扰素联合利巴韦林治疗慢性丙型肝炎疗效显著,可明显改善患者肝功能,具有较好的抗纤维化作用,值得临床推广和应用。Objective： To explore the clinical efficacy of interferon combined with ribavirin in treating chronic hepatitis C （CHC） and its impact on liver function and liver fibrosis indexes. Methods： 88 CHC patients in our hospital from March 2011 to March 2012 were randomly divided into two groups, and the control group （n=44） was treated with interferon while the observation group （n=44） was given interferon and ribavirin. The clinical effect and liver function and fibrosis changes were observed and compared between the two groups. Results： The overall effective rate of the observation group was 90.91%, which was significantly higher than the control group of 68.18% （P〈0.05）. After the treatment, the ALT, AST, HA, PC Ⅲ, C Ⅳand LN was （70.24± 7.94）, （79.45± 9.72）, （76.87± 10.32）, （79.45± 9.72）, （79.76± 8.00） and （118.41 ± 16.97） respectively in the observation group, which were significantly higher than before and these of the control group, the differences were statistieally significant （P〈0.05）. Conclusion： Interferon and ribavirin show good effect in treating CHC. They can significantly improve liver function and has anti-fibrosis function, which is worth clinical promotion and application.

关 键 词：干扰素 利巴韦林 慢性丙型肝炎 肝功能 肝纤维化指标 

分 类 号：R575.2[医药卫生—消化系统]