方剂配伍增加中药方剂活性——一项来自毒理学的实验研究  

Prescription compatibility can raise activity of Chinese medicine-An experimental research from toxicology

作　　者：史鹏程[1] 沈洪昇 胡人杰[1] 姚嫱[2] 

机构地区：[1]天津市医药科学研究所肿瘤药物研发中心,天津300020 [2]天津市人民医院,天津300121

出　　处：《天津中医药》2014年第9期567-569,共3页Tianjin Journal of Traditional Chinese Medicine

基　　金：天津市卫生局中医;中西医结合课题项目(07038)

摘　　要：[目的]比较不同制备方法对清热解毒方水煎剂毒性的影响。[方法]清热解毒方中各味药材分别制备成不同待测样品:合煎样品、分煎样品及单味药给药样品,采用简化机率法测定各样品对小鼠灌胃给药的半数致死量(LD50),并比较测定结果。[结果]所测得合煎样品和分煎样品的LD50分别为(91.26±7.92)g/kg和(111.47±9.12)g/kg,与合煎样品比较,分煎样品的毒性显著降低(P<0.05),且动物死亡时间及死前表现不同。单味药样品给药后多未出现明显毒性反应。[结论]与单味中药比较,复方配伍确能提高中药的生物活性。[Objective] To compare the effect of toxicity of Qingre Jiedu（clearing heat and detoxification） prescription in different preparation method. [Methods] The drugs contained in Qingre Jiedu prescription were prepared to different samples： single-decoction, mixed- decoction, and single-drug-decoction. The LD50 of each sample after intragastric administration was determined in mice by simplified probit method, and the results were compared. [Results] The LDs0 of mixed-decoction and single-decoction samples were （91.26±7.92） g/kg and （111.47±9.12 ） g/kg respectively. Compared with the mixed-decoction samples, the toxicity of single-decoction samples was de- creased significantly （P〈0.05）. Different death time and different behaviors before death were fund in animals. Single-drug-decoction sam- ples showed no toxic reaction in most animals after administration. [Conclusion] Compared with single-decoction sample and single-drug- decoction sample, compatible prescription has a certain effect of raising the bioaetivity of Chinese medicine.

关 键 词：清热解毒方 合煎 分煎 LD50 

分 类 号：R223.11[医药卫生—中医基础理论]