The mucosal immune system in the oral cavity——an orchestra of T cell diversity  

作　　者：Rui-Qing Wu Dun-Fang Zhang Eric Tu Qian-Ming Chen WanJun Chen 

机构地区：[1]Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health [2]State Key Laboratory of Oral Diseases,West China Hospital of Stomatology, Sichuan University

出　　处：《International Journal of Oral Science》2014年第3期125-132,共8页国际口腔科学杂志（英文版）

基　　金：supported by the Intramural Research Program of the National Institutes of Health;National Institute of Dental and Craniofacial Research, USA;supported by grant 2012DFA31370 from the International S&T Cooperation Program of China;the National Nature Science Foundation of China (81321002)

摘　　要：The mucosal immune system defends against a vast array of pathogens, yet it exhibits limited responses to commensal microorganisms under healthy conditions. The oral-pharyngeal cavity, the gateway for both the gastrointestinal and respiratory tracts, is composed of complex anatomical structures and is constantly challenged by antigens from air and food. The mucosal immune system of the oral-pharyngeal cavity must prevent pathogen entry while maintaining immune homeostasis, which is achieved via a range of mechanisms that are similar or different to those utilized by the gastrointestinal immune system. In this review, we summarize the features of the mucosal immune system,focusing on T cell subsets and their functions. We also discuss our current understanding of the oral-pharyngeal mucosal immune system.The mucosal immune system defends against a vast array of pathogens, yet it exhibits limited responses to commensal microorganisms under healthy conditions. The oral-pharyngeal cavity, the gateway for both the gastrointestinal and respiratory tracts, is composed of complex anatomical structures and is constantly challenged by antigens from air and food. The mucosal immune system of the oral-pharyngeal cavity must prevent pathogen entry while maintaining immune homeostasis, which is achieved via a range of mechanisms that are similar or different to those utilized by the gastrointestinal immune system. In this review, we summarize the features of the mucosal immune system,focusing on T cell subsets and their functions. We also discuss our current understanding of the oral-pharyngeal mucosal immune system.

关 键 词：mucosal immune system oral-pharyngeal mucosa T cell 

分 类 号：R781.5[医药卫生—口腔医学]