Mycophenolic acid derivatives from cultures of the mushroom Laetiporus sulphureu  

作　　者：FAN Qiong-Ying YIN Xia LI Zheng-Hui LI Yan LIU Ji-Kai FENG Tao ZHAO Bao-Hua 

机构地区：[1]College of Life Science, Hebei Normal University [2]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences [3]University of Chinese Academy of Sciences

出　　处：《Chinese Journal of Natural Medicines》2014年第9期685-688,共4页中国天然药物（英文版）

基　　金：supported by the National Basic Research Program of China(973 Program,No.2009CB 522300);the National Natural Sciences Foundation of China(Nos.30830113,U1132607)

摘　　要：AIM: To investigate the chemical constituents of the cultures of Laetiporus sulphureus(Bull.) Murrill. METHOD: Compounds were isolated and purified by various chromatographic techniques. The structure of the new compound was determined by interpretation of MS and 1D-, 2D-NMR spectroscopic data, while the known compounds were identified by comparison of their data with those reported. RESULTS: Three mycophenolic acid derivatives, 6-((2E, 6E)-3, 7-dimethyldeca-2, 6-dienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one(1), 6-((2E, 6E)-3, 7, 11-trimethyldedoca-2, 6, 10-trienyl)-5, 7-dihydroxy-4-methylphtanlan-1-one(2), and 6-((2E, 6E)-3, 7, 11-trimethyldedoca-2, 6, 10-trienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one(3) were isolated. CONCLUSION: Among them, compound 1 was new, and compound 2 exhibited moderate cytotoxicity against HL-60, SMMC-7721, A-549, and MCF-7 cells, with IC50 values of 39.1, 31.1, 27.4, and 35.7 μmol·L-1, respectively.AIM： To investigate the chemical constituents of the cultures ofLaetiporus sulphureus （Bull.） Murrill. METHOD： Compounds were isolated and purified by various chromatographic techniques. The structure of the new compound was determined by interpretation of MS and 1D-, 2D-NMR spectroscopic data, while the known compounds were identified by comparison of their data with those reported. RESULTS： Three mycophenolic acid derivatives, 6-（（2E, 6E）-3, 7-dimethyldeca-2, 6-dienyl）-7-hydroxy-5-methoxy-4-methylphtanlan-1-one （1）, 6-（（2E, 6E）-3, 7, 11-trimethyldedoca-2, 6, 10-trienyl）-5, 7-dihydroxy-4-methylphtanlan-1-one （2）, and 6-（（2E, 6E）-3, 7, 11-trimethyldedoca-2, 6, 10-trienyl）-7-hydroxy-5-methoxy-4-methylphtanlan-1-one （3） were isolated. CONCLUSION： Among them, compound 1 was new, and compound 2 exhibited moderate cytotoxicity against HL-60, SMMC-7721, A-549, and MCF-7 cells, with ICs0 values of 39.1, 31.1, 27.4, and 35.7μmol.L-1, respectively.

关 键 词：Laetiporus sulphureus Mycophenolic acid derivatives CYTOTOXICITY 

分 类 号：R284.1[医药卫生—中药学]