Hedgehog信号在胰腺炎症损伤中的作用机制  

Mechanisms of the Hedgehog signaling pathway in acute and chronic pancreatitis

作　　者：郑英强[1] 周翔宇[1] 李园[2] 

机构地区：[1]泸州医学院附属医院血管甲状腺外科,646000 [2]四川大学华西医院消化外科研究室,成都610000

出　　处：《国际免疫学杂志》2014年第5期371-375,共5页International Journal of Immunology

基　　金：国家自然科学基金（81100272）;泸州市科技基金（2011-5-37（5/7））

摘　　要：Hedgehog信号通路广泛参与多种器官急慢性炎症损伤、细胞再生和组织修复.尽管急性胰腺炎和慢性胰腺炎发病机制各异,在炎症损伤的同时,组织的自身修复和再生机制必然启动.国内外的研究已经证实,Hedgehog信号通路与其他信号通路发生交联反应,参与调节胰腺炎症程度、细胞再生以及纤维化,干预Hedgehog信号通路明显影响胰腺炎症进程和纤维化的程度.Aberrant activation of Hedgehog signaling plays multiple roles in acute and chronic inflam- matory injury, cell regeneration and tissue self-repair. In acute and chronic panereatitis, cell regeneration and tis- sue repair are triggered simultaneously. The hedgehog family is a group of secreted molecules that are essential for cell fate and patterning during the development. Studies have revealed that hedgehog signaling cross-talks with others signaling pathways in regulating inflammation, cell regeneration and fibrosis. Inhibition of hedgehog signal obviously influenced pancreatic inflammation and regeneration.

关 键 词：HEDGEHOG 急性胰腺炎 慢性胰腺炎 

分 类 号：R576[医药卫生—消化系统]