乳癌患者原发灶、复发灶中VEGF与Cath-D蛋白的表达  

Expressions of VEGF and Cath-D in primary and recurrent focuses from patients with breast cancer

作　　者：宁殿宾[1] 陈英敏[1] 暴雷[1] 

机构地区：[1]河北省人民医院普外一科,石家庄050051

出　　处：《郑州大学学报（医学版）》2014年第4期563-565,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:检测乳癌患者原发灶、复发灶中VEGF、组织蛋白酶D(Cath-D)蛋白的表达。方法:采用免疫组化SP法检测38例乳癌患者(有淋巴结转移者25例)和22例乳癌胸壁复发患者(有淋巴结转移者5例)原发灶、复发灶及有、无淋巴结转移组织中VEGF、Cath-D蛋白的表达。结果:正常乳腺组织,乳癌原发灶、复发灶中VEGF、CathD蛋白的表达差异有统计学意义(χ2=50.029和24.461,P<0.05),且乳癌原发灶、复发灶中VEGF、Cath-D蛋白的表达均高于正常乳腺组织,但二组织间差异无统计学意义。乳癌患者有淋巴结转移组VEGF、Cath-D蛋白的表达高于无淋巴结转移组(χ2=9.017和5.963,P<0.05)。乳癌组织中VEGF和Cath-D蛋白的表达呈正关联(rP=0.411,P<0.001)。结论:乳癌原发灶、复发灶及有淋巴结转移的乳癌组织中VEGF与Cath-D蛋白高表达,二者可能在乳癌复发和淋巴结转移中起协同作用。Aim： To investigate the expressions of VEGF and Cath-D in primary and recurrent focuses from patients with breast cancer. Methods： Immunohistochemical SP method was used to detect the expressions of VEGF and Cath-D in38 cases of breast cancer（ 25 with lymph node metastasis） and 22 cases of recurrent breast cancer（ 5 with lymph node metastasis）. Results： The expressions of VEGF and Cath-D in primary focuses and recurrent focuses had no significant difference,but both of them were higher than normal breast tissue（ χ2= 50. 029 and 24. 461,P 0. 05）. The expressions of VEGF and Cath-D in breast cancer tissue with lymphatic metastasis were higher than that of without lymphatic metastasis（ χ2= 9. 017 and 5. 963,P〈 0. 05）. The expressions of VEGF and Cath-D in breast cancer tissue were positively associated（ rP= 0. 411,P〈0. 001）. Conclusion： There are high expressions of VEGF and Cath-D in primary,recurrent focuses and breast cancer tissue with lymph node metastasis from patients with breast cancer,and they may have synergetic effect on the recurrence and lymphatic metastasis of breast cancer.

关 键 词：乳癌 血管内皮生长因子 组织蛋白酶D 淋巴结转移 

分 类 号：R737.9[医药卫生—肿瘤]