血浆催乳素水平与绝经后女性乳癌危险性的关系  

Relationship between plasma prolactin level and risk of breast cancer among postmenopausal women

作　　者：马瑞兰[1] 李国权[1] 张海琛[1] 邹丽娟[1] 

机构地区：[1]大连医科大学附属二院肿瘤放疗科,大连116023

出　　处：《郑州大学学报（医学版）》2014年第4期574-576,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的：评价血浆催乳素（PRL）水平与绝经后女性乳癌危险性的关系。方法：采用化学发光法测定83例绝经后女性乳癌病例和85例对照的血浆PRL水平,应用logistic回归分析绝经后血浆PRL水平与乳癌危险性的关系。根据肿瘤临床病理特征（肿瘤大小、病理类型、肿瘤分级以及ER是否阳性）对病例组进行分组,评估血浆PRL水平与不同乳癌亚组危险性的关系。结果：1病例组血浆PRL水平高于对照组（t=2.104,P=0.037）。2以血浆PRL〈P25为非暴露参考,血浆PRL P25-水平调整OR（95%CI）为1.04（1.01-2.83）,血浆PRL P50-水平调整OR（95%CI）为1.38（1.26-3.83）,血浆PRL≥P75水平调整OR（95%CI）为1.62（1.38-4.14）,χ2趋势=4.986,P=0.027。3PRL与绝经后乳癌危险性的关系在ER＋的肿瘤中略增强（χ2异质性=5.127,P=0.024）,在不同肿瘤大小、病理类型、肿瘤分级间无明显变化（P均〉0.05）。结论：血浆PRL水平与绝经后女性乳癌的危险性呈正相关,尤其是ER＋的乳癌。Aim： To estimate the association of plasma prolactin level with risk of breast cancer among postmenopausal women. Methods： By case-control study,the level of plasma prolactin was measured in 83 postmenopausal breast cancer patients and 85 controls by chemiluminescence. Logistic regression models were used to examine association of prolactin with breast cancer risk. In addition,we estimated the association across various case groups（ ductal vs lobular,tumor size≤2 cm vs 〉2 cm,ER＋vs ER-,well/moderately differentiated vs poorly differentiated）. Results： The plasma prolactin level of case group was significantly higher than that of control group（ t = 2. 104,P = 0. 037）. Increased risk of breast cancer was positively associated with elevated plasma level of prolactin[with 〈P25 of plasm prolactin level as unexposure reference,OR（ 95% CI） for P25-,P50-,and ≥P75was 1. 04（ 1. 01- 2. 83）,1. 38（ 1. 26- 3. 83）,and 1. 62（ 1. 38- 4. 14）,χ2trend= 4. 986,P = 0. 027]. The association was increased among ER＋cancer（ χ2heterogeneity= 5. 127,P = 0. 024）. Conclusion： It is suggested that high plasma level of prolactin is positively associated with increased breast cancer risk among postmenopausal women,especially for ER＋cancer.

关 键 词：乳癌 危险因素 催乳素 绝经后女性 

分 类 号：R737.9[医药卫生—肿瘤]