阻塞性睡眠呼吸暂停低通气综合征与不同性别急性脑梗死短期预后关系  

RELATIONSHIP BETWEEN OBSTRUCTIVE SLEEP APNEA HYPOPNEA SYNDROME AND SHORT-TERM PROGNOSIS OF ACUTE CEREBRAL INFARCTION IN DIFFERENT GENDERS

作　　者：邱石[1,2] 罗彬[1,2] 苗凤茹[1,2] 王培福[1,2] 李继来[1,2] 杜继臣[1,2] 

机构地区：[1]航天中心医院 [2]北京大学航天临床医学院神经内科,北京100049

出　　处：《河北医科大学学报》2014年第8期873-876,共4页Journal of Hebei Medical University

摘　　要：目的探讨阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)与急性脑梗死短期预后的关系及是否存在性别差异。方法选取急性脑梗死患者85例,所有患者均行多导睡眠图检查,根据睡眠呼吸暂停指数(apnea hyponea index,AHI)将患者为分为单纯脑梗死组37例,脑梗死伴轻度OSAHS组23例,脑梗死伴中重度OSAHS组25例,对所有患者在入院及出院时行美国国立卫生研究院卒中量表(national institute of health stoke scale,NIHSS)及Rankin量表(modified rankin scale,mRS)评分,比较3组神经功能缺损程度改善的情况且是否存在性别差异。结果与单纯脑梗死组相比,中重度OSAHS组出院时NHISS评分更高,出院时NIHSS评分及mRS评分下降值更低,差异均有统计学意义(P<0.05)。与男性单纯脑梗死组相比,男性中重度OSAHS组出院时NIHSS及mRS评分下降值评分下降值均更低,差异有统计学意义(P<0.01或<0.05),在女性中未发现此种差异。结论 OSAHS可能与男性急性脑梗死患者短期不良预后有关。Objective To determine whether an association exists between obstructive sleep apnea hypopnea syndrome（ OASHS）and short-term prognosis of acute cerebral infarction in different genders. Methods Patients with acute cerebral infarction（n = 85）were recruited and divided into pure cerebral infarction group（n = 37）,cerebral infarction with mild OSAHS group（ n = 23）and cerebral infarction with moderate to severe OSAHS group（n = 25）according to the monitoring results of apnea hyponea index（AHI）. The degree of neurologic impairment was assessed by National Institutes of Health Stroke Scale（NIHSS）and modified Rankin Score（mRS）on admission and before discharge. Results The NIHSS scores before discharge,the reduced values of NIHSS and mRS in the cerebral infarction with moderate to severe OSAHS group were significantly different from those in pure cerebral infarction group （P ﹤ 0. 05）. Significant difference in reduced values of NIHSS and mRS were also found in male（P ﹤0. 01 or ﹤ 0. 05）,but not in female. Conclusion The severity of OASHS is related to the increased risk of poor prognosis in male patients with acute cerebral infarction.

关 键 词：脑梗死 睡眠呼吸暂停 阻塞性 性别因素 

分 类 号：R733.3[医药卫生—肿瘤]