环境与遗传因素交互作用对老龄健康的影响——相关前期研究综述  

Effects of Interactions between Environmental and Genetic Factors on Health Aging:A Review on the Relevant Prior Research

作　　者：曾毅[1,2] 程令国[3] 阮荣平[4] 陈华帅[2,5] 李建新[6] 张风雨 陶伟[8] 顾军[8] 田小利[9] 

机构地区：[1]北京大学国家发展研究院健康老龄与发展研究中心 [2]Center for the Study of Aging and Human Development,Medical School of Duke University Durham 27710 [3]上海财经大学高等研究院 [4]中国人民大学农业与农村发展学院 [5]湘潭大学商学院 [6]北京大学社会学系 [7]Division of Clinical Sciences,Lieber Institute for Brain Development,Johns Hopkins University Baltimore 21205 [8]北京大学生命科学学院 [9]北京大学分子医学研究所人类群体遗传学研究室

出　　处：《医学与哲学（A）》2014年第9期1-6,25,共7页Medicine & Philosophy:Humanistic & Social Medicine Edition

基　　金：国家自然科学基金重点项目"关于改善老龄健康保障机制和科学管理效益的研究";项目编号:71233001;国家重点基础研究项目"血管衰老及相关疾病的生物学基础";项目编号:2013CB530700;NIA/NIH"Determinants of Healthy Longevity inChina";项目编号:R01AG023627

摘　　要：综述了环境与遗传交互作用对老龄健康影响的文献和国际研究进展,概述三个相关前期研究案例:FOXO基因类型与高龄老人60岁左右和当前喝茶的交互作用显著影响高龄老人健康,携带FOXO基因者喝茶对认知功能改善作用比不携带FOXO基因者显著要大;ADRB2-rs1042718或ADRB2-rs1042719基因类型与经常锻炼和参加社会休闲活动的交互作用对高龄老人认知功能和自评健康有显著改善;APOE4基因与生活重压交互作用会显著诱发老人自评健康差。根据研究分析结论,建议在保护个人隐私前提下,充分考虑环境因素与基因类型交互作用,实行有的放矢的健康干预方案,可能大大提高老龄健康干预效益。This paper presents a summarized review of the literature and international research program progress about investigations of effects of interactions between environmental and genetic factors （GxE） on health aging .We also briefly review three of our prior researches in this field ,including ：Interactions between carrying the FOXO genotypes and tea drinking around age 60 or at present were significantly associated with lower risk of cognitive disability at advanced ages ;Interactions between carrying the minor allele rs1042718 or rs1042719 of ADRB2 gene and regular exercise or social-leisure activities predicted significantly increased cognitive function and the likelihood of self-reporting good health at advanced ages ;Interactions between carrying the APOE4 genotype and the life stress factors significantly increased the risk of poor self-rated health among older adults .Our review and analysis imply that health promotion and intervention programs considering individuals’ genetic profiles as well as the GxE effects ,with appropriate protection of privacy/confidentiality , would yield increased benefits and reduced costs to the programs and their participants .

关 键 词：老龄健康 环境与遗传交互作用 健康干预 生活重压 基因类型 

分 类 号：R05[医药卫生]