血清唾液酸诊断女性恶性肿瘤的临床价值  

Clinical value of serum sialic acid in the diagnosis of malignant tumors of women

作　　者：邢雪花[1] 谢贤和[1] 王俏梅[2] 盛莉[1] 孙达统[1] 邱纯[1] 

机构地区：[1]海南省人民医院肿瘤内科,海南海口570311 [2]海南省人民医院检验科,海南海口570311

出　　处：《海南医学》2014年第17期2550-2551,共2页Hainan Medical Journal

摘　　要：目的探讨血清唾液酸测定对女性恶性肿瘤的临床价值。方法选择本院收治的225例女性恶性肿瘤患者(恶性肿瘤组)、同期来院体检的健康妇女169例(对照组)及月经期健康妇女150例(月经期组)作为观察对象,均应用美国贝克曼公司生产的全自动生化分析仪LX20测定血清唾液酸水平,比较三种不同人群血清唾液酸水平差异。结果恶性肿瘤组患者血清唾液酸为(87.4±13.2)mg/dl,明显高于对照组及月经期组,差异均有统计学意义(P<0.05),而对照组与月经期组比较差异无统计学意义(P>0.05);恶性肿瘤组唾液酸阳性157例,阴性68例,其阳性率显著高于对照组及月经期组(P<0.05),而对照组与月经期组比较差异无统计学意义(P>0.05);组织学类型恶性肿瘤组之间血清唾液酸水平差异均无统计学意义(P>0.05)。结论女性恶性肿瘤血清唾液酸水平升高,检测其水平有助于女性肿瘤病情评估及预后,具有重要临床价值。Objective To investigate the clinical value of serum sialic acid in the diagnosis of malignant tumors in women. Methods 225 cases of female patients with malignant tumor treated in our hospital were selected as malignant tumor group, 169 cases of healthy women were selected as the control group during the same period, and 150 cases of healthy women during menses were evolved in menstrual period group. The serum sialic acid levels of all cases were detected with LX20 automatic biochemical analyzer produced by USA Backman company. The levels of serum sialic acid in different groups were compared. Results The serum sialic acid in malignant tumor group was （87.4 ± 13.2） mg/dl, which was significantly higher than that in the control group and the menstrual period group （P〈0.05）. There was no significant difference between control group and menstrual period group in the value of serum sialic acid （P〉0.05）. There were 157 positive cases and 68 negative cases in malignant tumor group, the positive rate in which was significantly higher than that in control group and the menstrual period group （P〈0.05）, while there was no significant difference in the positive rate between the control group and the menstrual period group （P〉0.05）. In malignant tumor group, there were no significant differences in the serum sialic acid levels between different pathological types. （P〉0.05）. Conclusion The level of serum sialic acid increases in woman with malignant tumor, which has important clinical value in evaluation and prognosis of that disease.

关 键 词：血清唾液酸 女性 恶性肿瘤 临床价值 

分 类 号：R730.43[医药卫生—肿瘤]