双柏散外敷治疗急性胆囊炎外治技术探讨  

Discussion on Shuangbai Powder External Application in Treatment of Acute Cholecystitis

作　　者：王百林[1] 翟淑萍[1] 刘增军[1] 刘秋玲[1] 程海坤 王蕊[1] 王新华[2] 陈汝福[3] 曹杰[4] 刘安重[5] 谭志建[6] 彭林[7] 万鹏[8] 方坚[9] 仲永[10] 

机构地区：[1]广州中医药大学第一附属医院肝胆外科,广东广州510405 [2]广州医学院,广东广州510405 [3]中山大学第二附属医院肝胆外科,广东广州510405 [4]广州市第一人民医院,广东广州510405 [5]广州医学院第一附属医院肝胆外科 [6]广东省中医院肝胆外科,广东广州510405 [7]广东省人民医院普通外科,广东广州510405 [8]重庆市北碚区中医院外科,重庆400700 [9]广州中医药大学第三附属医院外科,广东广州510405 [10]徐州市中心医院普通外科,江苏徐州221000

出　　处：《辽宁中医杂志》2014年第9期1806-1810,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家十一五支撑计划资助课题(2008BAI53B034)

摘　　要：目的:观察双柏散外敷治疗急性胆囊炎患者的临床疗效,及其不同外敷技术参数方案对其临床疗效的影响,确定双柏散外敷的最佳外治技术方案。方法:本研究对符合方案分析集分析(简称PPS)的250例急性胆囊炎进行前瞻性临床研究,分为对照组和双柏散治疗组,后者根据不同的赋形剂、敷贴时间和敷贴剂量又分为7个双柏散治疗组。观察各组的症状总分与改善、右上腹痛改善时间、腹部压痛改善时间、腹部反跳痛改善时间的指标改变。结果:(1)临床疗效:生存分析检验结果显示两组在腹痛改善时间和压痛缓解时间方面,差异有统计学意义(P<0.05)。(2)不同试验组与疗效指标的关系:1各组比较右上腹痛改善时间存在显著性差异(P<0.001)。改善时间最短的为100 g蜜7 h组;2腹部压痛改善时间差异有统计学意义(P<0.001);3各组患者反跳痛改善时间比较没有显著性差异(P>0.05)。结论:研究表明加味双柏散外敷治疗急性胆囊炎疗效明确,推荐外治技术方案为双柏散100 g,蜜为赋形剂,敷贴7 h,外敷腹哀穴,每日两次。Objective ： To observe the clinical efficacy of Shuangbai Powder external application for the patients with acute cho- lecystifis and the effect of the clinical efficacy with different technical parameter programs of external application, determining the best external application program of Shuangbai Powder. Methods ：This research was a prospective clinical study on the 250 patients with acute choleeystitis which were analyzed by per - protocol population set （ PPS ）. The patients were divided into the control group and the treatment group, and the treatment group was divided into seven groups according to the different excipients, appli- cator time and applicator doses. It was to observe the relationships of different groups with the improvement of the symptom score, the time of the right upper quadrant pain improvement, the abdominal tenderness improvement and the abdominal rebound tender- ness improvement in each group. Results ： （ 1 ） Clinical efficacy ： the survival analysis of the test results indicated that the difference between the control group and the treatment group had statistical significance on the abdominal pain improvement time and the ab- dominal tenderness time （ P 〈 0.05 ）. （ 2 ） The relationship between different test groups and the efficacy indexes ： the difference a- mong the different groups about right upper quadrant pain improvement time was statistically significant （P 〈 0. 001 ）. The group of the shortest improvement time was the 100 g honey 7 hours one;the difference about the abdominal tenderness improvement time had statistics significance （P 〈 0. 001 ） ;the difference about the rebound pain improvement time did not have a statistics sig- nificance （P 〉 O. 05 ）. Conclusion：The study shows that the treatment efficacy for acute cholecystitis by Shuangbai Powder was definite, and the recommended external technology treatment program is 100g of the Shuangbai Powder with honey for the excipient and seven hours for external application time,

关 键 词：双柏散 急性胆囊炎 中医外治 疗效 

分 类 号：R575.61[医药卫生—消化系统]