小牛血清去蛋白肠溶胶囊对癫痫患者认知功能及丙二醛的影响  

Effect of deproteinised calf serum enteric-coated capsules on cognitive function of patients with epilepsy

作　　者：张宁[1] 刘学文[1] 刘轶丹[1] 张信芳[1] 

机构地区：[1]辽宁医学院附属第一医院神经内科,锦州121001

出　　处：《中国医师进修杂志》2014年第25期19-22,共4页Chinese Journal of Postgraduates of Medicine

基　　金：辽宁省科技厅社会发展基金（2012225019,2014022030）

摘　　要：目的检测癫痫患者的认知功能，探讨小牛血清去蛋白肠溶胶囊（DCSECC）对脑功能的影响及作用机制。方法将66例癫痫患者按抽签法随机分为试验组和对照组，每组33例，两组均规范服用抗癫痫药，试验组口服DCSECC5mg/d，连续服用3个月。分别于治疗前及治疗后1，2，3个月行韦氏记忆量表（WMS，转换为记忆商）和蒙特利尔认知评估量表（MoCA）评分，检测事件相关电位P300潜伏期和丙二醛浓度。并与33例健康体检者（健康组）进行比较。结果试验组和对照组治疗前记忆商、MoCA评分均明显低于健康组[（80．4±14．2），（79．6±13．9）分比（103．2±30．1）分，（13．5±4．5），（12．9±3．9）分比（28．8±8．7）分]，P300潜伏期、丙二醛明显大于健康组[（380．8±49．7），（389．5±50．4）ms比（309．8±44．7）ms，（5．0±1．8），（4．8±1．7）μmol／L比（2．2±0．6）μmol／L]，差异有统计学意义（P〈0．05）；试验组治疗后3个月记忆商[（96．5±18．3）分]、MoCA评分[（26．8±7．7）分]较治疗前明显增加，P300潜伏期[（321-3±36．1）ms]及治疗后2，3个月丙二醛[（3．02±1．04），（2．99±1．01）μmol／L]较本组治疗前明显降低，差异有统计学意义（P〈0．05）；对照组治疗前后记忆商、MoCA评分比较差异无统计学意义（P〉0．05）。治疗过程中未出现与服用DCSECC有关的明显不良反应。结论癫痫患者认知功能明显减退，DCSECC能显著改善患者的认知功能，其作用机制可能是通过抗氧化实现的。Objective To investigate the effect of deproteinised calf serum enteric-coated capsules （DCSECC） on cognitive function of patients with epilepsy. Methods Sixty-six patients were randomly divided into two groups including experimental group who received DCSECC 5 mg/d, 3 times a day and antiepileptics,and control group who received antiepileptics. To detect the cognitive function by means of Wechlors memory scale （WMS） , Montreal cognitive assessment （MoCA）, event related potentials （P300） latency period and malondialdehyde （MDA） before treatment and after treatment for 1,2,3 months, and compared with 33 healthy subjects controls （healthy group）. Results Compared with healthy group, the scores of memory quotient （MQ） and MoCA were signifiantly decreased in experimental group and control group [ （80.4±14.2）, （79.6± 13.9） scores vs. （ 103.2 ± 30.1 ） scores; （ 13.5 ± 4.5）, （ 12.9 ±3.9） scores vs. （28.8 ＋8.7） scores],in the mean time,P300 latency period and MDA were signifiantly prolonged [ （380.8 ±49.7 ）, （389.5±50.4） ms vs.（309.8 ± 44.7 ） ms; （5.0 ±1.8 ）, （4.8 ±1.7） μmol/L vs. （2.2 ± 0.6） mol/L],there was significant difference （P 〈 0.05 ）. Compared with the control group after treatment for 3 months, the scores of MQ and MoCA in experimental group [（96.5 ±18.3） scores, （26.8± 7.7） scores] were increased and P300 latency period [（321.3±36.1） ms] was shortened, there were significant differences （P 〈 0.05）. The level of MDA decreased significandy in experimental group after 2,3 months treatment [ （ 3.02± 1.04 ）, （2.99± 1.01 ） μmol/L ], there was significant difference （P 〈 0.05 ）. The scores of MQ and MoCA in control group after treatment had no significant difference compared with before treatment （P 〈 0.05）. Conclusions The cognitive function in patients with epilepsy is decreased. DCSECC medical treatment can improve the cognitive function by means of antioxidant activity.

关 键 词：癫痫 韦氏记忆量表 蒙特利尔认知评估量表 事件相关电位 小牛血清去 蛋白肠溶胶囊 

分 类 号：R742.1[医药卫生—神经病学与精神病学]