局部进展期胃癌根治术后同期放化疗与单纯化疗的对照研究  

Control study of concurrent chemoradiotherapy and chemotherapy after locally advanced gastric cancer radical operation

作　　者：吴隆秋[1] 施华球[1] 王祥财[1] 叶建明[1] 鄢俊[1] 谢瑞莲[1] 

机构地区：[1]赣南医学院第一附属医院肿瘤科,341000

出　　处：《中国实用医药》2014年第25期1-3,共3页China Practical Medicine

摘　　要：目的对照研究局部进展期胃癌根治术后同期放化疗与单纯化疗的治疗效果。方法 42例局部进展期胃癌患者,依据随机数字表法分为同期放化疗组(RCT组)和化疗组(CT组),每组21例。评价其不良反应,并统计1、2、3年局控率及生存率。结果 RCT组患者的1、2、3年生存率均明显比CT组高(P<0.05),平均生存时间明显比CT组长(P<0.05),局部淋巴结转移率、腹腔内淋巴结复发率、远处转移率均明显比CT组低(P<0.05),术后用药的Ⅲ、Ⅳ级白细胞数减少、粒细胞数减少发生率均明显比CT组低(P<0.05)。结论局部进展期胃癌根治术后同期放化疗的治疗效果明显比单纯化疗好。Objective To make a control study of the curative effects of concurrent chemoradiotherapy and chemotherapy after locally advanced gastric cancer radical operation. Methods A total of 42 cases of locally advanced gastric cancer were divided into two groups by random number table method as concurrent chemoradiotherapy group （RCT group） and chemotherapy （CT group）, and each group contained 21 cases. The adverse reactions, local control rate and survival rates in 1 year, 2 years and 3 years. Results The survival rates in 1 year, 2 years and 3 years of the RCT group were obviously higher than those of the CT group （P〈0.05）. The average survival time was significantly longer in the RCT group than in the CT group （P〈0.05）. The rates of regional lymph node metastasis and intraperitoneal lymph node recurrence, distant metastasis were significantly lower in the RCT group than in the CT group （P〈0.05）. The decreasing of grade III and grade IV white blood cell by postoperative medication and the incidence of decreased granulocyte were lower in the RCT group than in the CT group （P〈0.05）. Conclusion The curative effect of concurrent chemoradiotherapy is better than chemotherapy after locally advanced gastric cancer radical operation.

关 键 词：局部进展期胃癌根治术 同期放化疗 单纯化疗 

分 类 号：R735.2[医药卫生—肿瘤]