精神分裂症患者QTc间期延长的影响因素  

Influencing factors of QTc interval prolongation in schizophrenia inpatients

作　　者：吕建宝[1] 曹文胜[1] 康燕霞[1] 韩瑞俊[1] 李娟[1] 

机构地区：[1]北京回龙观医院,100096

出　　处：《神经疾病与精神卫生》2014年第4期375-377,共3页Journal of Neuroscience and Mental Health

基　　金：基金项目：北京市卫生局青年基金资助项目（QN2009-033）

摘　　要：目的 调查精神分裂症患者心电图QTc间期延长及相关影响因素。方法 对服用稳定剂量抗精神病药的522例住院精神分裂症患者进行横断面调查，收集人口学资料，测定空腹血糖等生化指标，并进行心电图检查，以QTc≥440ms作为QTc间期延长标准，分析QTc间期延长状况及其相关因素。结果 QTc间期延长发生率12．8％，女性（22．7％）高于男性（7．8％），差异有统计学意义（P〈0．01），心电图窦性心动过速和传导阻滞患者QTc间期延长风险分别是心电图正常患者的2．6和3．1倍（P〈0．05）。结论 抗精神病药治疗期间QTc间期延长发生率存在性别差异，女性QTc间期延长的风险可能更高。Objective To investigate the corrected QT interval （QTc） prolongation prevalence of schizophrenia inpatients and relative factors. Methods In this cross-sectional study, a total of 522 inpatients were investigated, all the patients met ICD 10 criteria for schizophrenia, the demographic data were collected, the electrocardiograph examinations were taken and the blood samples were drawn, the electrocardiograms （ECG） and serum biochemical indexes were measured. QTc intervals were calculated according Bazett＇s formula, prolonged QTc was defined as ≥440 ms, QTc prolongation and relative fac- tors were analyzed. Results The total ratio of QTc prolongation was 12.8%, the QTc prolongation ratio of female group （22.7%） was higher than male group （7.8%） （P 〈 0.01）, the QTc prolongation risks of patients with sinus tachycardia and conduction block were 2.6 （OR= 2.6,95% CI： 1.2--5.6） and 3.1 （OR =3.1,95% CI： 1.1--8.4） times of patients with normal electrocardiogram respectively （P〈 0.05）. Conclusions Maybe there are gender differences in QTc prolongation during the period of antipsychotics treatment, female are at higher risk of QTc prolongation than male.

关 键 词：精神分裂症 抗精神病药 QTC间期 性别差异 横断面调查 

分 类 号：R749.3[医药卫生—神经病学与精神病学]