Sox2转录因子在肺癌患者体内表达的临床价值分析  

Analysis of Sox2 transcription factor in clinical value in patients with lung cancer in vivo expression

作　　者：席菁乐[1] 崔斐[1] 谢剑明[1] 黄娜[1] 王淳邻[1] 

机构地区：[1]南方医科大学南方医院肿瘤科,广州510515

出　　处：《中国医学前沿杂志（电子版）》2014年第8期124-126,共3页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的研究Sox2转录因子在肺癌患者体内的表达情况。方法选取本院2011年12月至2013年6月治疗的肺癌患者120例,检测其体内Sox2转录因子的表达情况。结果肺癌患者癌组织中Sox2阳性表达率为90%,表达水平得分为(5.19±0.87)分,均显著高于癌旁组织中Sox2阳性表达率及表达水平得分(χ2=166.9565;t=46.1893;P=0.0000);鳞癌患者癌细胞内Sox2阳性表达水平最高,其次为大细胞癌;腺癌Sox2阳性表达水平最低;鳞癌、大细胞癌Sox2表达水平与腺癌、小细胞癌相比差异具有极其显著性(P<0.01);癌细胞低分化程度的患者体内Sox2阳性表达水平最高,随着分化程度的增加,Sox2阳性表达水平逐渐下降,肺癌高、中、低分化组差异显著(t=5.7745,8.6034,4.2127;P=0.0000)。结论肺癌组织Sox2转录因子阳性表达率高于癌旁组织,肺癌组织Sox2转录因子在不同病理分型、不同癌细胞分化程度组织中的表达水平不同,通过检查Sox2转录因子表达水平差异对肺癌诊断及治疗方案的确定具有一定的参考价值。Objective To study the expression of Sox2 transcription factors in lung cancer patients. Method Selected 120 lung cancer patients in our hospital from December 2011 to June 2013, used to detect the expression of transcription factor Sox2 in vivo. Result The positive rate of Sox2 expression was 90% incarcinoma tissues of patients with lung cancer, the expression level of intensity score was （5.19± 0.87）; were significantly higher than that of positive expression rate and intensity scores in expression of Sox2 in cancer tissue （x2 = 166.9565, t =46.1893, P = 0.000）; the positive expression of Sox2 squamous cell cancer the cell was the highest, followed by large cell carcinoma; adenocarcinoma, the positive expression of Sox2 minimum; squamous cell carcinoma, large cell carcinomaand adenocareinoma, the expression level of Sox2 in small cell carcinoma had a very significant difference （P 〈 0.01）; cancer cells with low differentiation degree in patients with positive Sox2 expression level was the highest, with increasing differentiation degree, Sox2 positive expression level decreased, lung cancer, significant differences in high, low differentiation group （t = 5.7745, 8.6034, 4.2127; P = 0.0000）. Conclusion The positive expression rate is higher than the adjacent tissues of cancer lung cancer tissue Sox2 transcription factor, expression level of Sox2 transcription factor of lung cancer in different pathological types, different cancer cell differentiation of tissues of different level difference, has the certain reference value to the diagnosis and treatment of lung cancer is determined by examining the expression of the Sox2 transcription factor.

关 键 词：肺癌 Sox2转录因子 体内表达 

分 类 号：R734.2[医药卫生—肿瘤]