首发抑郁症患者脑区低频振幅特征与症状群的相关性  

Amplitude of low frequency fluctuation in first-episode depression and its relationship with the separate symptom clusters： a resting-state fMRI study

作　　者：阎锐[1] 姚志剑[1] 汤浩[1] 韦茂彬[2] 陈建淮[1] 花玲玲[1] 卢青[2] 

机构地区：[1]南京医科大学附属脑科医院抑郁症专科,南京210029 [2]东南大学学习科学研究中心

出　　处：《中华行为医学与脑科学杂志》2014年第8期673-675,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目（81371522,61372032）,江苏省医学专项（BL2012052）,江苏省自然科学基金项目（BK2012740,BK20131074）

摘　　要：目的 探讨首发抑郁症患者脑局部神经元自发性活动能量特征与临床症状群的相关性.方法 对22位首发抑郁患者和26位性别、年龄相匹配的健康对照,进行3.0T磁共振扫描.以受教育年限为协变量,比较两组受试脑区低频振幅（ALFF）值,将有统计学差异的脑区ALFF均值与临床症状群严重程度进行相关分析.结果 患者组较对照组右额中回（9,45,-6;K=18）和双侧梭状回（-34,-19,-12;K=37和30,-33,-18;K=31）ALFF值增高,左楔前叶（0,-72,42; K=19）ALFF降低（P＜0.05,Alphasim矫正）.右额中回、右梭状回和左楔前叶ALFF值,分别与体质量因子分、阻滞因子分和睡眠障碍因子分呈负相关（r=-0.494,P=0.019;r=-0.486,P=0.022和r=-0.484,P=0.023）,其余相关性无统计学意义（P＞0.05）.结论 首发抑郁症患者特定症状群的严重程度与静息状态下脑局部神经元活动强度异常有关.Objective To explore the relationship between energy feature of the spontaneous neural activity and separate symptom clusters in first-episode depression.Methods 22 first-episode depression patients and 26 age-,gender-matched healthy controls were scanned with 3.0 T MRI Scanner.The t-test was employed to compare the difference of amplitude of low frequency fluctuation （ALFF） between the two groups,and the correlation analyses were conducted between ALFF of brain regions with significant difference and the severity of depressive symptoms clusters.Results Compared with healthy group,the depression group showed significantly increased ALFF in the right middle frontal gyrus （9,45,-6; K =18） and the bilateral fusiform gyrus （-34,-19,-12; K =37 and 30,-33,-18 ; K =31,respectively）,and decreased ALFF in the left precuneus （0,-72,42; K =19） （P＜0.05,corrected by Alphasim）.The ALFF of the the right middle frontal gyrus,the right fusiform gyrus,and the left precuneus were negative correlated with the scores of weight factor,retardation factor and sleep disturbance factor （r=-0.494,P=0.019; r=-0.486,P=0.022 and r=-0.484,P=0.023,respectively）.Conclusion Abnormal energy feature of the spontaneous neural activity may be associated with severity of specific depressive symptoms clusters in first-episode depression patients during resting-state.

关 键 词：抑郁症 静息态 低频振幅 临床症状 

分 类 号：R749.4[医药卫生—神经病学与精神病学]