三维适形放疗联合化疗治疗Ⅲ期非小细胞肺癌的疗效研究  

Efficacy of simultaneous chemotherapy and three dimensional conformal radiation therapy in treating patients with nonsmall cell lung cancer at stageⅢ

作　　者：赵一虹[1] 许卫东[1] 

机构地区：[1]北京军区总医院放射治疗科,北京100700

出　　处：《检验医学与临床》2014年第17期2387-2388,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨三维适形放疗联合化疗治疗Ⅲ期非小细胞肺癌的临床效果。方法将2011年3月至2013年3月于本院治疗的120例Ⅲ期非小细胞肺癌患者分为对照组与观察组。对照组给予传统放疗联合化疗,观察组给予三维适形放疗联合化疗。比较两组患者的疗效及不良反应发生情况。结果两组患者近期疗效总控制率以及放疗40Gy时、放疗结束时、放疗结束后1个月肌钙蛋白水平比较差异均有统计学意义(P<0.05)。治疗后放射性食管炎、放射性肺炎发生率组间比较差异无统计学意义(P>0.05)。结论三维适形放疗联合化疗治疗Ⅲ期非小细胞肺癌能够提高近期疗效,避免心肌损伤,但存在一定程度的急性不良反应。Objective To explore clinical efficacy of simultaneous chemotherapy and three dimensional confor-mal radiation therapy in treating patients with non-small cell lung cancer at stage Ⅲ .Methods A total of 120 pa-tients with non-small cell lung cancer at Ⅲ stage ,treated in this hospital from Mar .2011 to Mar .2013 ,were divided into control group ,receiving conventional radiotherapy and chemotherapy ,and observation group ,receiving three-di-mensional conformal radiotherapy and chemotherapy .Curative efficacy and incidence of adverse events were compared between the two groups .Results Total control rate ,and levels of troponin detected at radiation therapy of 40 Gy ,at the end of radiotherapy and one month after radiotherapy were with statistical between the two groups （P〈0 .05） . Incidence rates of radioactive esophagitis and radioactive pneumonia were without significant differences （P〉0 .05） . Conclusion Application of combined chemotherapy and three-dimensional conformal radiotherapy for the treating of non-small cell lung cancer at Ⅲ stage could improve recent efficacy and avoid myocardial injury ,but might be with a-cute adverse events .

关 键 词：三维适形放疗 化疗 Ⅲ期非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]