血清肿瘤标志物NSE、CA-125在非霍奇金淋巴瘤诊断及预后判定中的临床价值  

Clinical significance of serum tumor makers NSE,CA125 in the diagnosis and prognosis assessment of non-Hodgkin's lymphoma

作　　者：房丽[1] 王轶楠[1] 马守东[1] 肖建波[1] 李海丽[1] 王玲玲[1] 刘翠华 

机构地区：[1]河北省唐山市人民医院放化科,063000 [2]河北省唐山市丰润区韩城医院

出　　处：《河北医药》2014年第20期3051-3054,共4页Hebei Medical Journal

摘　　要：目的探讨血清肿瘤标志物NSE和CA-125在非霍奇金淋巴瘤(NHL)中的表达情况及临床意义。方法采用电化学发光免疫测定法测定56例NHL患者血清肿瘤标志物NSE和CA-125的表达水平,判定NSE和CA-125的表达与NHL患者临床特征及其预后的相关性。结果 56例NHL患者化疗前血清NSE值(34.63±8.54)μg/L,CA-125(47.59±9.53)μg/L,均明显高于对照组,差异有统计学意义(P<0.05);且NSE、CA-125表达水平的高低与NHL患者B症状、临床分期、IPI预后指数及治疗效果等临床特征相关(P<0.05)。结论血清肿瘤标志物NSE、CA-125联合定量检测可提高NHL诊断敏感性,同时对NHL临床分期、疗效判定及预后等方面具有一定临床意义。Objective To investigate the clinical significance of the two serum tumor markers-neuron specific enolase （NSE） and carbohydrate antigen 125 （CA-125） in the diagnosis and prognosis evaluation of non-Hodgkin＇ s lymphoma （NHL）. Methods The serum levels of NSE and CA-125 in 56 patients with NHL were measured by electroche miluminescence immunoassay. The correlation between the expressions of NSE, CA125 and clinical characteristics as well as prognosis of patients with NHL were analyzed. Results Before chemotherapy the serum levels of NSE [ （34. 63 ±8.54） μg/L] and CA-125 [ （47.59 ±9.53） μg/L] in 56 patients with NHL were significantly higher than those in control group （ P 〈0.05 ） ,furthermore ,the expression levels of NSE and CA-125 were correlated with patient＇s symptoms, clinical stage, IPI prognosis index and therapeutic effect. Conclusion The quantitive detection of NSE combined with CA125 plays an important role in diagnosis,clinical staging and prognosis assessment for patients with NHL,which can increase diagnostic sensitivity.

关 键 词：神经元特异性烯醇化酶 糖链核心蛋白抗原 非霍奇金淋巴瘤 肿瘤标志物 

分 类 号：R730.4[医药卫生—肿瘤]