Protein Requirements in Healthy Adults: A Meta-analysis of Nitrogen Balance Studies  

作　　者：LI Min SUN Feng PIAO Jian Hua YANG Xiao Guang 

机构地区：[1]Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention [2]School of public health, Peking university

出　　处：《Biomedical and Environmental Sciences》2014年第8期606-613,共8页生物医学与环境科学（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81001247)

摘　　要：Objective The goal of this study was to analyze protein requirements in healthy adults through a meta-analysis of nitrogen balance studies. Methods A comprehensive search for nitrogen balance studies of healthy adults published up to October 2012 was performed, each study were reviewed, and data were abstracted. The studies were first evaluated for heterogeneity. The average protein requirements were analyzed by using the individual data of each included studies. Study site climate, age, sex, and dietary protein source were compared. Results Data for 348 subjects were gathered from 28 nitrogen balance studies. The natural logarithm of requirement for 348 individuals had a normal distribution with a mean of 4.66. The estimated average requirement was the exponentiation of the mean of the log requirement, 105.64 mg N/kg·d. No significant differences between adult age, source of dietary protein were observed. But there was significant difference between sex and the climate of the study site （P〈0.05）. Conclusion The estimated average requirement and recommended nutrient intake of the healthy adult population was 105.64 mg N/kg·d （0.66 g high quality protein/kg·d） and 132.05 mg N/kg·d （0.83 g high quality protein/kg·d）, respectively.Objective The goal of this study was to analyze protein requirements in healthy adults through a meta-analysis of nitrogen balance studies. Methods A comprehensive search for nitrogen balance studies of healthy adults published up to October 2012 was performed, each study were reviewed, and data were abstracted. The studies were first evaluated for heterogeneity. The average protein requirements were analyzed by using the individual data of each included studies. Study site climate, age, sex, and dietary protein source were compared. Results Data for 348 subjects were gathered from 28 nitrogen balance studies. The natural logarithm of requirement for 348 individuals had a normal distribution with a mean of 4.66. The estimated average requirement was the exponentiation of the mean of the log requirement, 105.64 mg N/kg·d. No significant differences between adult age, source of dietary protein were observed. But there was significant difference between sex and the climate of the study site （P〈0.05）. Conclusion The estimated average requirement and recommended nutrient intake of the healthy adult population was 105.64 mg N/kg·d （0.66 g high quality protein/kg·d） and 132.05 mg N/kg·d （0.83 g high quality protein/kg·d）, respectively.

关 键 词：Protein requirement Nitrogen balance Estimated average requirement Recommendednutrient intake 

分 类 号：R151[医药卫生—营养与食品卫生学]