药代动力学开放式双室模型在直肠癌CT灌注成像中的应用  

Application of open two-compartment model of pharmacokinetics in rectal cancer CT perfusion imaging

作　　者：董玉姝[1] 杨春静[2] 金银华 刘屹[1] 徐荣天[1] 佟咸利[1] 李建平[2] 朱晓珍[2] 刘建刚[2] 

机构地区：[1]中国医科大学附属第一医院放射科,辽宁沈阳110001 [2]九江市第一人民医院CT室,江西九江332000 [3]吉化集团公司总医院影像中心,吉林长春132000

出　　处：《中国医学影像技术》2014年第9期1377-1381,共5页Chinese Journal of Medical Imaging Technology

基　　金：江西省卫生厅科学技术计划项目(20133204);辽宁省科技厅科学技术计划项目(2013225049);辽宁省教育厅科学研究一般项目(L2013313)

摘　　要：目的研究药代动力学开放式双室模型在直肠癌CT灌注成像中的应用。方法对36例由结肠镜及术后病理证实的直肠癌患者术前行CT平扫,选定靶平面后,行CT灌注扫描。根据CT灌注参数,绘制靶平面肿瘤组织ROI及靶血管(肿瘤供血动脉)的时间-密度曲线。根据药代动力学开放式双室模型计算公式推导肿瘤内血浆隔室容积百分比(fP)、组织间隙隔室容积百分比(fI)、表观血流量(F)及表面通透性(PS)。结果 36例直肠癌的fP值为(17.3±7.4)%,fI值为(34.3±11.6)%,F值为(141.0±47.8)ml/(min·100g),PS值为(43.2±18.8)ml/(min·100g)。结论药代动力学开放式双室模型为定量评价直肠肿瘤组织内微循环的特性提供了新的思路,具有潜在的临床应用价值。Objective To explore the application of open two-compartment model of pharmacokinetics in rectal cancer CT perfusion imaging. Methods Thirty-six patients with pathologically confirmed rectal adenocarcinoma underwent CT scan preoperative. After seletcting target plane, the CT perfusion imaging was performed. According to CT perfusion parame- ters, the time-density curve was obtained of target plane ROI and target vessels （tumor feeding artery）. Relative volume fraction of the plasma compartment （fe）, relative volume fraction of the interstitial compartment （fl）, apparent plasma flow （F） and permeability-surface area product （PS） were calculated by open two-compartment model of pharmacokinetics. Results The values of fp, fi, Fand PS were （17.3±7.4）%, （34.3±11.6）%, （141.0±47.8）ml/（min.100 g） and （43.2±18.8）ml/（min. 100 g）, respectively. Conclusion Open two-compartment model of pharmacokinetics provides a new method in evaluating microvascularity of rectal cancers with CT, and had potential clinical applications.

关 键 词：药代动力学开放性双室模型 结直肠肿瘤 灌注成像 体层摄影术 X线计算机 

分 类 号：R735.3[医药卫生—肿瘤]