^(18)F-FDG PET/CT结直肠癌总病灶糖酵解与淋巴结转移及淋巴管生成的关系  

Correlation of total lesion glycolysis on ^(18)F-FDG PET/CT images with lymphatic metastasis and lymphangiogenesis in colorectal carcinoma

作　　者：田墨涵[1] 于丽娟[1] 秦誉[1] 王大龙[1] 王欣[1] 李迎辞[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院PET/CT-MRI中心,黑龙江哈尔滨150081

出　　处：《中国医学影像技术》2014年第9期1382-1386,共5页Chinese Journal of Medical Imaging Technology

基　　金：黑龙江省卫生厅科研课题(2012-671)

摘　　要：目的探索结直肠癌(CRC)PET/CT显像总病灶糖酵解(TLG)与其淋巴管密度(LVD)和血管内皮细胞生长因子-C(VEGF-C)的关系。方法回顾分析36例病理证实的CRC患者(淋巴结转移组19例,无淋巴结转移组17例)的术前PET/CT资料,记录最大标准摄取值(SUVmax)和TLG。以免疫组化分析肿瘤和正常黏膜葡萄糖转运蛋白-1(GLUT-1)和VEGF-C的表达,D2-40标记淋巴管,记数LVD,分析其与SUVmax及TLG的关系。结果 CRC组织VEGF-C和GLUT-1阳性表达率显著高于正常黏膜(P均<0.01)。淋巴结转移组的SUVmax、TLG、LVD和VEGF-C显著高于无淋巴结转移组(SUVmax:t=3.602,P=0.001;TLG:t=3.421,P=0.002;LVD:t=3.051,P=0.004;VEGF-C:χ2=8.047,P=0.045)。SUVmax与TLG、TLG与LVD、TLG与GLUT-1的累积光密度(IOD)值存在直线相关关系(r=0.607、0.654、0.367,P均<0.05)。VEGF-C不同表达等级间TLG和LVD差异有统计学意义(F=5.922、35.579,P均<0.001)。GLUT-1与VEGF-C的表达水平呈等级相关(r=0.302,P单侧=0.028)。结论结直肠癌病灶的TLG与LVD和VEGF-C存在正相关,TLG可在一定程度上反映肿瘤淋巴结转移和淋巴管生成状况。Objective To explore correlation of total lesion glycolysis （TLG） with lymphatic vessel density （LVD） and expression level of vascular endothelial growth factor-C （VEGF-C） in coloreetal cancer （CRC）. Methods Retrospective analysis of 36 patients with CRC （19 cases with lymphatic metastasis, 17 cases without lymphatic metastasis） proved by pathology and underwent PET/CT examination before surgical operation. The maximum standardized uptake value （SUVmax） and TLG were recorded. Immunohistochemistry was used to analyze the expression of VEGF-C of tumor tissue and the normal mucosal tissue. D2-40 was used to mark the lymphatic endothelial cells, LVD was recorded, and their correlation with SUV and TLG were analyzed. Results Positive expression of glucose transporter protein 1 （GLUT-l） and VEGF-C in tumor tissue were remarkably higher than those of normal mucosal tissue （all P〈0.01）. Statistically significant differences of SUV TLG, LVD and VEGF-C were found between lymphatic metastatic and non-lymphatic metastatic patients （SUVmax ： t=3. 602, P〈0. 001; TLG： t=3. 421, P=0. 002; LVD： t=3. 051, P〈0. 004; VEGF-C.. X2= 8. 047, P=0. 045）. In tumor tissue, there were linear correlation between SUVmax and TLG, TLG and LVD, TLG and integral optical density （IOD） of GLUT-1 （r=0. 607, 0. 654, 0. 367, all P〈0.05）. TLG and LVD in different groups of VEGF-C were statistically significant （F= 5. 922, 35. 579, all P〈0. 001）. The expression level of GLUT-1 and VEGF-C were rankly correlated （r=0. 302, P〈0. 028）. Conclusion TLG is positive correlated with LVD and VEGF-C, indicating that TLG may reflect lymphangiogenesis and lymphatic metastasis in CRC in some degree.

关 键 词：结直肠肿瘤 体层摄影术 发射型计算机 单光子 总病灶糖酵解 血管内皮细胞生长因子受体-3 肿瘤转移 

分 类 号：R735.3[医药卫生—肿瘤]