多聚唾液酸(PSA)及其修饰的神经粘附分子(PSA-NCAM)对肿瘤及细胞信号通路的影响  

The impact of polysialic acid(PSA) and polysialylated neural cell adhesion molecule(PSA-NCAM) on tumor and cell signaling pathways

作　　者：王欣[1,2] 关锋[1,2] 

机构地区：[1]江南大学,糖化学与生物技术教育部重点实验室,无锡214122 [2]江南大学生物工程学院,无锡214122

出　　处：《遗传》2014年第8期739-746,共8页Hereditas（Beijing)

基　　金：国家自然科学基金项目(编号:81201572)资助

摘　　要：神经粘附分子(Neural cell adhesion molecule,NCAM)是免疫球蛋白家族中的一员,在细胞粘附和细胞通信,尤其是神经系统的生长和塑型中起重要作用。而多聚唾液酸(Polysialic acid,PSA)则是控制NCAM粘附能力形成与神经系统分化的重要因素。研究发现,多种肿瘤细胞中存在PSA以及多聚唾液酸化的神经粘附分子(PSA-NCAM)再表达的现象,预示PSA及PSA-NCAM与多种肿瘤细胞的粘附性、迁移性和侵袭性等特性密切相关,影响肿瘤细胞的生长与转移,并通过介导多种细胞信号通路影响癌症的发生与发展。文章综述了NCAM以及PSA对癌症的发生与发展、预后的作用及其功能对细胞下游信号传导的影响。The neural cell adhesion molecule （NCAM）, the member of the immunoglobulin superfamily, plays an important role in regulating cell adhesion and cell communication, particularly in nervous system wiring and plasticity. Polysialic acid, which is attached to NCAM on cell surface, is a prominent regulator of neural cell migration and differentiation during nervous system development. It has been demonstrated that PSA and PSA-NCAM were re-expressed in some malignant tumors. It was indicated that PSA and PSA-NCAM were tightly associated with cell adhesion, migration and invasion, and mediated tumor development and progression through certain cell signalingpathways. Here, we summarize the functional role of PSA, PSA-NCAM and related cell signaling pathways in tumor development, progression and prognostic.

关 键 词：多聚唾液酸 信号通路 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]