钴铬合金表面掺铁二氧化钛膜对变形链球菌抗菌性能的实验研究  

Experimental study on antibacterial properties of Fe^(3+)-doped TiO_2 film on Co-Cr alloy against Streptococcus mutans

作　　者：杜劲英[1] 穆锦全[1] 万乾炳[2] 李建[3] 

机构地区：[1]南京市妇幼保健院口腔科,江苏南京210004 [2]四川大学华西口腔医院修复科,四川成都610041 [3]南京医科大学附属口腔医院特诊科,江苏南京210029

出　　处：《口腔医学》2014年第8期584-587,共4页Stomatology

摘　　要：目的探讨掺杂Fe3+的二氧化钛(TiO2)薄膜在体外对变形链球菌的抗菌效果。方法采用溶胶-凝胶法在钴铬合金表面制备纯TiO2薄膜和Fe3+不同掺杂量的TiO2薄膜,然后以未制备TiO2膜的钴铬合金为对照组,采用贴膜法测试纯TiO2薄膜和Fe3+掺杂的TiO2薄膜分别在紫外光、荧光灯、黑暗条件下对变形链球菌的抗菌活性,并测定最佳抗菌活性时Fe3+掺杂量。结果在不同光照条件下,纯TiO2薄膜组和Fe3+掺杂的TiO2薄膜组的抗菌效果与对照组比较差异均有统计学意义(P<0.05)。在紫外光和黑暗条件下薄膜最佳抗菌活性时Fe3+/Ti的摩尔比为2%,荧光灯下为1.5%。结论掺Fe3+的TiO2薄膜抗菌活性高于未掺杂Fe3+的,且在黑暗中也可有一定的抗菌活性,可通过调整Fe3+的掺杂量控制其抗菌活性。Objective To study the antibacterial properties of Fe3 ＋ -doped TiO2 film against Streptococcus mutans. Methods Pure TiO2 film and Fe3＋ -doped TiO2 films were prepared by a sol-gel technique with dip coating method on Co-Cr alloy. With the cobalt-chromium alloy ser- ving as the control group ,the antibacterial properties of pure TiO2 film and Fe3＋ -doped TiO2 films against Streptococcus mutans were evaluated with sticking-membrane method under ultraviolet （UV） ,fluorescent light and in the darkness. The doping content of Fe3 ＋ was measured as the antibacterial property was at its best. Results Under different lighting conditions,the antibacterial effects of pure TiO2 film group and Fe3＋ - doped TiO/film were statistically different compared with the control group （ P 〈 0.05 ）. The Fe3＋ -doped TiO2 film appeared good antibacterial activity with the n（Fe3＋）/n（Ti） of 2% under UV and dark conditions,while n（Fe3＋）/n（Ti） of 1.5% under fluorescent light. Conclusions The Fe3＋ -doped TiO2 film has more active antibacterial property than the pure TiO2 film,and it may also have certain antibacterial activity in the darkness. The antibacterial activity can be controlled by adjusting the relative ratio of n（Fe3＋）/n（Ti）.

关 键 词：二氧化钛薄膜 溶胶-凝胶法 铁离子掺杂 抗菌性能 

分 类 号：R783.1[医药卫生—口腔医学]