三联组氨酸核苷酸结合蛋白1与人类疾病  

Histidine Triad Nucleotide-binding Protein 1 and Human Diseases

作　　者：党永辉[1] 刘仲伟[2] 陈峰[3] 郭坤[4] 王家蓓 

机构地区：[1]西安交通大学医学发部法医学院卫生部法医学重点实验室教育部环境与疾病相关基因重点实验室,西安710061 [2]陕西省人民医院心血管内科,西安710061 [3]南京医科大学法医学系,南京210029 [4]西安交通大学医学部第一附属医院肝胆外科,西安710061 [5]Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Baltiore, Baltiore MD 21201

出　　处：《中国医学科学院学报》2014年第4期454-460,共7页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(81171262,81371473);中央高校基本科研业务费专项资金(2011JDHZ59)~~

摘　　要：三联组氨酸核苷酸结合蛋白1(HINT1)是三联组氨酸蛋白超家族成员之一,三联组氨酸因为具有保守的核苷酸结合基序组氨酸-x-组氨酸-x-组氨酸-xx(x代表1个疏水氨基酸)而得名,HINT1广泛参与肿瘤、神经精神疾病等人类疾病的病理生理过程。本文主要综述HINT1的结构、分布、酶活性基本功能,以及与人类疾病的关联。Histidine triad nucleotide-binding protein 1 （HINT1） is a member of a superfamily of histidine triad proteins named by the conserved nucleotide-binding motif histidine-x-histidine-x-histidine-xx,in which x represents hydrophobic amino acid.HINT1 is implicated in pathological progress of many human diseases including cancer and schizophrenia; however,little is known about the essential role and pathological consequences of HINT1 in cellular physiology and diseases.Therefore,we summarize the structure,distribution,and physiological function of HINT1 in cells and tissues as well as the correlation between HINT1 and human diseases.

关 键 词：三联组氨酸核苷结合蛋白1 肿瘤 神经精神疾病 2型糖尿病 肝脏缺血 再灌注 肝纤维化 

分 类 号：R394.3[医药卫生—医学遗传学]