GSK-3β参与神经精神疾病的研究进展  

Progress on GSK-3β participating in neuropsychiatric disorders

作　　者：唐倩倩[1,2] 郭小云[1,2] 刘迪[1,2] 曹君利[1,2,3] 

机构地区：[1]江苏省麻醉学重点实验室 [2]江苏省麻醉与镇痛应用技术重点实验室,江苏徐州221004 [3]徐州医学院附属医院麻醉科,江苏徐州221002

出　　处：《中国药理学通报》2014年第9期1193-1196,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金重点项目(No 81230025);国家自然科学基金面上项目(No 81070888)

摘　　要：糖原合成酶激酶-3β(glycogen synthase kinase-3β,GSK-3β)是一种丝氨酸/苏氨酸激酶,最初发现是糖原合成过程中的关键酶。在神经系统中,GSK-3β通过转录激活、细胞增殖与细胞分化参与神经系统的多种病理生理过程。GSK-3β活性异常引起其下游的信号蛋白及基因表达异常,导致与其底物相关的如双极紊乱、精神分裂症、阿尔采末病及疼痛等多种神经精神疾病的发生。近年来,GSK-3β已成为基础和临床研究的热点,也逐渐成为众多疾病的治疗靶点。该文就GSK-3β参与神经精神疾病的机制做简要论述。Glycogen synthase kinase-3β（ GSK-3β） is a serine-threonine kinase,which was originally identified as a key regula-tor of glycogen metabolism. In nervous system, GSK-3β partici-pates in many central and peripheral nervous system physiological processes through transcription,cell proliferation and differentia-tion. The abnormal activity of GSK-3βinduces downstream signa-ling molecules and gene expression abnormalities,which are in-volved in some neuropsychiatric disorders such as schizophrenia, bipolar disorder,Alzheimer＇s disease,and pain. In recent years, lots of basic and clinic researches focus on GSK-3β,which might gradually become critical theraptic target of many diseases. The article mainly reviews the mechanisms involved in abnormal acti-vation of GSK-3β related neuropsychiatric disorders.

关 键 词：GSK-3Β PI3K WNT信号通路 双极紊乱 精神分裂症 阿尔采末病 疼痛 

分 类 号：R-05[医药卫生] R345.57