内生大麻素受体激动剂抑制异动症大鼠纹状体单胺类神经递质的释放  

Cannabinoid receptor agonist WIN 55,212-2 inhibits striatal monoamine release in a rat model of L-DOPA-induced dyskinesia

作　　者：王勇[1] 张格娟[1] 王涛[1] 王会生[1] 刘健[1] 

机构地区：[1]西安交通大学医学院生理学与病理生理学系,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2014年第5期586-590,共5页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家自然科学基金资助项目(No.81100837);中国博士后科学基金(No.2013M532059)~~

摘　　要：目的观察内生大麻素受体激动剂WIN 55,212-2对帕金森病左旋多巴相关异动症模型大鼠纹状体内单胺类神经递质释放的影响。方法采用脑内微透析和高效液相色谱在线递质测量法观察WIN 55,212-2腹腔内注射对异动症模型大鼠左旋多巴相关异动症状和纹状体内单胺类神经递质释放的影响。结果与溶剂注射相比,WIN 55,212-2注射显著抑制异动症模型大鼠左旋多巴皮下注射后的异动样症状(F1 263=44.071,P<0.001),同时明显减少纹状体内多巴胺的释放(F1 263=5.091,P<0.05)。结论纹状体内生大麻素受体可能通过抑制性的调节单胺类神经递质的释放来影响异动症模型大鼠的异动样症状。Objective To explore the effects of cannabinoid receptor agonist WIN 55,212-2 on striatal monoamine release in a rat model of L-DOPA-induced dyskinesia （LID）.Methods Effects of WIN 55,212-2 on striatal monoamine release in LID rats were observed by intracerebral microdialysis and high-performance liquid chromatography.Results The dyskinetic behavior related to L-DOPA was inhibited significantly by the injection of cannabinoid receptor agonist WIN 55,212-2 （F1263 =44.071,P＜0.001）,accompanied by significant decrease of striatal dopamine release （F12633-5.091,P＜0.05）.Conclusion The results suggest that cannabinoid receptor may be involved in mediating the dyskinetic behavior related to L-DOPA through the regulation of striatal monoamine release.

关 键 词：帕金森病 异动症 纹状体 多巴胺 去甲肾上腺素 大鼠 大麻素受体激动剂 

分 类 号：R741[医药卫生—神经病学与精神病学]