异种角膜移植前景展望  

Prospects of corneal xenotransplantation

作　　者：安慧娟[1] 江雯[2] 鲍玉洲[1] 

机构地区：[1]郑州大学人民医院眼科河南省眼科研究所&河南省立眼科医院,450003 [2]第三军医大学实验动物学教研室,重庆400038

出　　处：《中华实验眼科杂志》2014年第9期848-851,共4页Chinese Journal Of Experimental Ophthalmology

摘　　要：角膜移植供体缺乏是一个亟待解决的难题.研究表明,与其他系统的器官移植相比较,角膜组织的免疫赦免特性使角膜移植不易发生免疫排斥反应,猪角膜的结构和生物力学与人角膜相似性较高,经过基因改造,降低免疫排斥反应使猪角膜植片具有作为人类角膜移植片替代品的潜力.就目前所了解的异种角膜移植的排斥机制,基因工程猪的最新研究进展以及猪角膜作为异种移植供体的可行性进行综述.Donor shortage in corneal transplantation is an emerging issue.Recent studies showed that compared with other organ transplantation,the rejection of corneal transplantation is weak due to the immune privilege,and the anatomical and biomechanical properties of human corneas are similar to pig corneas,so genetically engineered pigs have great potentials as a new source for clinical transplantation.This review discussed current knowledge of the pathogenesis of the rejection mechanism,recent advances in gene engineering pig,and feasibility of porcine xenocorneal graft.

关 键 词：角膜 异种移植 排斥反应 猪 

分 类 号：R779.65[医药卫生—眼科]