干扰素治疗慢性肝炎疗效观察  

Curative effect of interferon in the treatment of chronic hepatitis

作　　者：石亚玲[1] 

机构地区：[1]广州市第八人民医院检验科,广东省广州510060

出　　处：《中国基层医药》2014年第20期3138-3140,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：探讨注射用重组人干扰素α-1b对慢性肝炎的疗效及观察干扰素中和抗体（ NA）对疗效的影响。方法选择慢性肝炎80例，按随机数字表分为对照组40例和治疗组40例，HBV DNA含量用荧光定量聚合酶链反应法（ PCR）测定，抗干扰素中和抗体的采用抗病毒中和生物法测定。结果观察组治疗后平均血清HBV DNA含量明显低于治疗前（F＝12．55，P＜0．05）；对照组治疗前后差异无统计学意义（F＝0．68， P＜0.05）；NA阳性组治疗前后HBV DNA含量差异无统计学意义（F＝0．88，P＞0．05）；NA阴性组治疗前后HBV DNA含量差异有统计学意义（F＝11．55，P＜0．05）；80例中，细胞病变程度0级10例；1级25例；2级：25例；3级：12例；4级8例。结论注射用重组人干扰素α-1b治疗慢性肝炎有一定的疗效，但NA能影响治疗效果。Objective To investigate the effect of recombinant interferon in the treatment of chronic hepatitis and the influence of neutralizing antibody （NA） on its clinical efficacy.Methods 80 cases with chronic hepatitis were randomly divided into the treatment group（n=40） and control group（n=40）.The content of HBV DNA was determined by fluorescence quantitative polymerase chain reaction （ PCR） assay.The neutralizing antibodies against interferon were measured by antiviral-neutralizing assay（AVA）.Results After the treatment,the content of HBV DNA in the observation group was significantly lower than before treatment （F=12.55,P〈0.05）.The contents of HBV DNA in the control group had no significant difference before and after treatment （F=0.68,P〉0.05）.The contents of HBV DNA in NA positive group had no significant difference before and after treatment （F=0.88,P〉0.05）;The contents of HBV DNA in NA negative group had significant difference before and after the treatment （ F=11.55,P〈0.05）.In 80 cases,degree of cell lesions in 0 grade（10 cases）,1 grade（25 cases）,2 grade （25 cases）,3 grade （12 cases） and 4 grade（8 cases）.Conclusion The recombinant interferon in the treatment of chronic hepatitis has certain effect,but NA can affect its treatment effect .

关 键 词：肝炎 慢性 干扰素 干扰素中和抗体 

分 类 号：R575.1[医药卫生—消化系统]