气相色谱-质谱联用法检测药品包装用聚氯乙烯类硬片材料中5种邻苯二甲酸酯类塑化剂的研究  

The research on a GC-MS method for simultaneous determination of 5 kinds of phthalate plasticizers in polyvinyl chloride sheet

作　　者：陈泱 沈好文 裘婧 朱必林 

机构地区：[1]江苏省医疗器械检验所,南京210012

出　　处：《药物分析杂志》2014年第9期1650-1653,共4页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的：建立气相色谱-质谱联用方法,用于检测药品包装用聚氯乙烯类硬片材料中5种邻苯二甲酸酯类塑化剂。方法：气相色谱分离,质谱定性分析,外标法定量分析。结果：5种邻苯二甲酸酯类塑化剂浓度在1.9-17μg·mL-1范围内呈线性,r均大于0.99;在0.2-8.0 mg·kg-1添加浓度范围内的平均回收率为94.1%-104.9%,RSD为1.1%-4.7%（n=6）。结论：该法用于检测药品包装用聚氯乙烯类复合硬片聚氯乙烯类硬片材料中5种邻苯二甲酸酯类塑化剂,并能够适应大规模样品的快速分析要求。Objective：To investigate a GCMS method for simultaneous determination of 5 kinds of phthalate plasticizers in polyvinyl chloride sheet. Methods：Phthalate plasticizers in the sample were separated by gas chromatography. Meanwhile,the mass spectrometry was applied for qualitative analysis and external standard method was utilized for quantitative analysis. Results：External standard curves for 5 kinds of phthalate plasticizers were in good linear relationship in the range of 1. 917 μg·mL1（ r 〉0.99）,the average recovery within the added concentration range of 0. 28. 0 mg·kg1was 94. 1%104. 9% and RSD was 1. 1%4. 7%（ n = 6）. Conclusion：This work provided an effective,accurate and highly sensitive method for the rapid detection of huge quantity of samples.

关 键 词：气相色谱-质谱联用 聚氯乙烯类复合硬片 邻苯二甲酸酯 塑化剂 药品包装材料 安全监测 快速分析 

分 类 号：R917[医药卫生—药物分析学]