子宫内膜样腺癌伴鳞状上皮分化患者的临床病理学与预后分析  

Analysis on the clinical pathological features and prognosis of endometrial adenocarcinoma with squamous epithelial differentiation

作　　者：邹国桢 冯一中[2] 李海 

机构地区：[1]江苏省苏州市吴江区第一人民医院病理科,215200 [2]苏州大学附属第二医院病理科 [3]江苏省昆山市第一人民医院病理科

出　　处：《中国现代医药杂志》2014年第9期47-49,共3页Modern Medicine Journal of China

摘　　要：目的分析并评价子宫内膜样腺癌并发鳞状上皮分化患者的临床病理学特点及预后状况。方法选择48例子宫内膜样腺癌伴鳞状上皮分化患者作为观察组,同期住院的59例子宫内膜样腺癌不伴有鳞状上皮分化患者作为对照组,对比分析两组临床病理特征、治疗及预后状况。结果两组患者在年龄与临床病理特征方面相比无统计学差异(P>0.05);两组间肿瘤分期均接近(P均>0.05);观察组肿瘤高分化程度显著低于对照组(P=0.008),存在统计学意义;其中的中分化及低分化肿瘤比例均高于对照组,但未见统计学差异(P均>0.05);观察组浸润肌层程度≥1/2者少于对照组(P>0.05);两组淋巴结转移状况间比较无明显差异(P>0.05),不具有统计学意义。两组间手术治疗及辅助治疗方法相比无明显差异(P均>0.05),不具有统计学意义。两组平均随访(31.6±17.5)个月,观察组死亡与复发占8.33%,对照组占5.08%,两组相比无明显差异(P>0.05),不具有统计学意义。结论子宫内膜样腺癌并发鳞状上皮分化主要为中低分化类型,但同单纯子宫内膜样腺癌患者相比,其病理学特征及预后并无显著性差异,两者临床治疗方法基本相同。Objective To analyze and evaluate the clinical pathological features and prognosis of endometrial adenoearcinoma with squamous epithelial differentiation. Methods Selected 48 endometrial adenocarcinoma patients with squamous differentiation as observation group,59 endometrial adenocarcinoma patients without squamous epithelial differentiation at the same period as control group ,compared the clinical pathological characteristics ,treatment and prognosis between two groups. Results There was no statistical difference in the age,the clinical pathologic characteristics and cancer stage between two groups （P〉0.05）. The high degree of differentiation of tumor in observation group was significantly lower than that of the control group （P=0.008）. The proportion of moderate and low differentiated tumors in observation group were higher than the control group,but it had no statistical difference （P〉0.05）. Patients with muscular infiltration degree equal to or greater than 1/2 was fewer in observation group than the control group （P〉0.05）. There was no significant difference between the two groups on lymph node metastasis, surgical treatment and auxiliary treatment （P〉0.05）. The average follow-up period of two groups was 31.6±17.5 months. There was no statistical difference between the rate of death and recurrence in observation group （8.33%） and the control group （5.08%）,P〉0.05. Conclusion Endometrial adenocarcinoma with squamous differentiation mainly occurs in the moderate and low differentiated tumors. However,its clinical treatment,prognosis and clinical treatment are the same as endometrial adenocarcinoma.

关 键 词：子宫内膜样腺癌 鳞状上皮分化 病理特征 预后分析 

分 类 号：R737.33[医药卫生—肿瘤]