雷帕霉素在延缓衰老及老年相关性疾病中的研究进展  

Research advances in rapamycin delaying aging and age-related diseases

作　　者：任月英 吴文 

机构地区：[1]杭州华东医药集团新药研究院有限公司,杭州310012

出　　处：《中国抗生素杂志》2014年第9期715-720,共6页Chinese Journal of Antibiotics

摘　　要：随着生物学家对雷帕霉素(西罗莫司)靶蛋白(target of rapamycin,TOR)研究的深入,发现雷帕霉素通过抑制哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,m TOR)的活性影响细胞的生长、增殖、蛋白质合成和细胞自噬,从而延长了无脊椎动物和哺乳动物的生命周期,并预防和延缓了老年相关性疾病的发生。本文对雷帕霉素在延缓衰老及预防老年相关性疾病中的研究进展进行综述。With more in-depth research in target of rapamycin （TOR）, biologists discovered that rapamycin extends the lifespan of invertebrates and mammals, as well as prevents and delays age-related diseases, by inhibiting the activity of mammalian target of rapamycin （mTOR） to impact cell growth and proliferation, protein synthesis, and cell autophagy. This paper reviews the research developments in Rapamycin delaying aging and preventing age- related diseases.

关 键 词：雷帕霉素 MTOR 长寿 衰老 神经变性疾病 

分 类 号：R979.5[医药卫生—药品]