三联疗法与序贯疗法在肝硬化高氨血症患者中根除幽门螺杆菌的疗效观察  

Efficacy of triple therapy and sequential therapy in the eradication of Helicobacter pylori in liver cirrhosis patients with hyperammonia

作　　者：贺庆娟[1] 刘奎香[2] 赵亚楠[1] 孙颖[1] 王成喜[1] 

机构地区：[1]青岛市第八人民医院消化内科,山东青岛266100 [2]青岛市第八人民医院眼科,山东青岛266100

出　　处：《中国现代医生》2014年第26期148-149,152,共3页China Modern Doctor

基　　金：山东省青岛市中医科研计划(2009-zyy017)

摘　　要：目的探讨肝硬化高氨血症患者采用三联疗法与序贯疗法根除Hp的效果观察。方法选择肝硬化高氨血症并Hp感染阳性的患者共68例,随机分为三联根除组和序贯根除组。结果两组的Hp根除率分别为79.4%(27/34)和85.3%(29/34),差异无统计学意义(χ2=0.41,P>0.05)。三联根除组治疗前与治疗后、治疗后1个月相比,血氨浓度下降显著(t分别为4.02、5.11,P均<0.01);序贯根除组治疗前与治疗后、治疗后1个月相比,血氨浓度亦下降显著(t=4.68、5.83,P均<0.01),但两组间血氨浓度同步下降的幅度均无统计学差异(P>0.05)。结论肝硬化高氨血症患者采用三联疗法与序贯疗法根除Hp的疗效无显著差异。Objective To explore the efficacy of triple therapy and sequential therapy in the eradication of helicobacter pylori in liver cirrhosis patients with hyperammonia （Hp）. Methods A total of sixty-eight liver cirrhosis patients with hyperammonia and positive Hp infection were randomly divided into triple eradication group and sequential eradication group. Results The eradication rates of Hp in triple therapy group and sequential therapy group were 79.4% （27/34） and 85.3% （29/34） respectively. There was no significant difference between the two groups （x2=0.41, P〉0.05）. In the triple therapy group, the blood ammonia concentration of after treatment and one month after withdrawal of drugs de- creased significantly compared with before the treatment （t=4.02, 5.11, P〈0.01）.In the sequential therapy group, the blood ammonia concentration of after treatment and one month after withdrawal of drugs decreased significantly com- pared with before the treatment （t=4.68, 5.83, P〈0.01 ）.The fall of ammonia concentration was not statistical different between the two groups （P〉0.05）. Conclusion There is no significant difference in Hp eradication between triple therapy and sequential therapy in liver cirrhosis patients with hyperammonia.

关 键 词：肝硬化高氨血症 幽门螺杆菌 三联疗法 序贯疗法 

分 类 号：R575.2[医药卫生—消化系统]