海马的谷氨酸信号通路与精神分裂症  

Hippocampus glutamate signaling pathway and schizophrenia

作　　者：王洪忠 鹿勇[2] 李莉[2] 谢峰[2] 

机构地区：[1]山东省潍坊市潍城区人民医院内科,山东潍坊261000 [2]菏泽医学专科学校病理学教研室,山东菏泽274030

出　　处：《中国现代医生》2014年第26期158-160,共3页China Modern Doctor

基　　金：山东省高等学校科技计划项目(J11LC02)

摘　　要：多项研究表明谷氨酸信号转导系统与精神心理疾病的发生有着密切的关系。谷氨酸通路在中枢神经系统尤其是在海马区对神经元的生长和突触可塑性发挥着重要的作用。本文从海马的结构和功能出发,对海马内的谷氨酸信号转导通路及与精神分裂症的发生进行综述,以更深入地了解海马认知功能及精神分裂症的发生机制。A number of studies indicate that the glutamate signal transduetion system is closely related with the oc- currence of mental disorders. A glutamate pathway in the central nervous system, especially in the hippocampus neu- ron, plays an important role in neuron growth and synaptic plasticity. In this paper, the relationship of glutamate sig- naling pathway in the hippocampus and the incidence of schizophrenia is reviewed by exploring the structure and function of the hippocampus in order to better understand the pathogenesis of schizophrenia.

关 键 词：海马 谷氨酸 信号转导 精神分裂症 

分 类 号：R749[医药卫生—神经病学与精神病学]