VEGF与Ang-2在人肾上腺组织中的表达  

Expression of VEGF and Ang-2 in adrenal hyperplasia and adrenal tumor

作　　者：李丹丹[1] 白悦心[2] 庞妩燕[1] 

机构地区：[1]河南大学淮河医院内分泌科,河南开封475000 [2]郑州大学第一附属医院内分泌科,河南郑州450052

出　　处：《中国现代医学杂志》2014年第25期39-43,共5页China Journal of Modern Medicine

摘　　要：目的探讨VEGF和Ang-2在肾上腺肿瘤和肾上腺增生组织中的表达。方法应用免疫组化技术比较52例肾上腺肿瘤、26例肾上腺增生组织和7例正常肾上腺组织中VEGF和Ang-2蛋白表达的差异,并分析其与肾上腺增生和肿瘤组织病理特征的关系。结果肾上腺瘤中VEGF蛋白阳性表达率为65.38%(34/52),高于肾上腺增生组织的34.61%(9/26)和正常肾上腺组织的0.0%(0/7),差别有显著性(P<0.05),肾上腺瘤中Ang-2蛋白阳性表达率为61.54%(32/52),高于肾上腺增生组织的26.92%(7/26)和正常肾上腺组织的0.0%(0/7),且差别有显著性(P<0.05)。且肾上腺外、多发、恶性肿瘤中VEGF和Ang-2蛋白表达量均高于肾上腺内(P<0.05)、单发(PP<0.05)、良性和直径<5 cm的嗜铬细胞瘤(P<0.05)。肾上腺增生组织VEGF和Ang-2表达高于正常肾上腺组织,但差异无显著性。结论 VEGF和Ang-2可能通过促进肾上腺肿瘤血管生成参与调节了肿瘤的增殖,肾上腺肿瘤VEGF和Ang-2的表达可能与肿瘤的侵袭有关。VEGF和Ang-2表达水平升高可能是肾上腺增生发生的原因之一。【Objective】To investigate the expression of angiopoietin-2（Ang-2） and vascular endothelial growth factor（VEGF） and angiopoietin-2（Ang-2） in adrenal tumor and adrenal hyperplasia.【Methods】Totally 85 primary human adrenal gland were collected, including 52 adrenal tumor, 26 adrenal hyperplasia and 7 normal adrenal samples collected from patients operated for renal carcinoma. The VEGF protein and Ang-2 protein were detected by SABC immunohistochemistry, and the correlation was analyzed. 【Results】The positive expression rate of VEGF were 65.38%（34/52） in adrenal tumor and 34.61%（9/26） in adrenal hyperplasia, showing a significant difference between adrenal tumor and adrenal hyperplasia（P〈0.05）. The positive expression rate of Ang-2 was 61.54%（32/52） in adrenal tumor, showing a significant difference between adrenal hyperplasia 26.92%（7/26）（P〈0.05）. There were correlation between Ang-2 and VEGF expression level and different clinical-pathological factors including tumor＇s volume, location and property. The expression of Ang-2 or VEGF in adrenal hyperplasia was higher than those in normal adrenal, though there was no statistical difference existed in these two kinds of results.【Conclusions】The high expression of Ang-2 and VEGF in adrenal tumor indicates that both of them play important role in tumor growth and invasion. The high expression of Ang-2 and VEGF may play a role in the occurring of adrenal hyperplasia.

关 键 词：肾上腺肿瘤 肾上腺增生 ANG-2 VEGF 免疫组化 

分 类 号：R586.9[医药卫生—内分泌]