缺血性脑血管病患者血浆溶血磷脂酸极性相似总磷脂与椎动脉峰时的临床研究  

Clinical study on plasma lysophosphatidic acid similar polarity of total phospholipids and vertebral artery peak in patients with ischemic cerebrovascular disease

作　　者：郝树森[1] 李军[1] 高连生[1] 杨晓玲[1] 常宁[1] 康红霞[1] 张丽英[1] 刘皇哲 

机构地区：[1]石家庄市第八医院内科,河北石家庄050081

出　　处：《中国医药导报》2014年第27期42-43,47,共3页China Medical Herald

基　　金：河北省科学技术研究与发展计划项目(编号122777114)

摘　　要：目的探讨缺血性脑血管病患者血浆溶血磷脂酸极性相似总磷脂（AP）及椎动脉峰时的情况。方法收集2012年10月~2013年2月在石家庄市第八医院内科住院的缺血性脑血管病患者220例（缺血性脑血管病组）,分为脑梗死组（110例）与短暂性脑缺血发作（TIA）组（110例）,并选取同时期在门诊进行体检100名健康体检者作为对照组。采用比色法检测AP,彩色多普勒超声显像仪作椎动脉峰时测定。结果缺血性脑血管病组、脑梗死组和TIA组的AP的检测阳性率（93.6%、96.3%、90.9%）及椎动脉峰时延长的阳性率（94.5%、90.9%、98.1%）显著高于对照组（55.0%、35.0%）,差异有高度统计学意义（P〈0.01）,而脑梗死组和TIA组两组间AP的阳性率及椎动脉峰时阳性比较,差异无统计学意义（P〉0.05）;缺血性脑病组的AP、椎动脉峰时检测分别为（6.54±1.88）U、（0.163±0.013）s,与对照组[（5.82±1.03）U、（0.148±0.016）s]比较,差异有统计学意义（P〈0.05）。结论缺血性脑血管病与AP及椎动脉峰时有关。Objective To explore the situation of plasma lysophosphatidic acid of total phospholipids （AP） and verte- bral artery peak in patients with ischemic cerebrovascular disease. Methods From October 2012 to February 2013, at department of Internal Medicine in the Eighth Hospital of Shijiazhuang City,220 patients with ischemic cerebrovascular disease patients hospitalized were selected （ischemic cerebrovascular disease group）, divided into cerebral infarction group （110 cases） and transient ischemic attack （TIA） group （110 cases）, at the same period, 100 cases health examina- tion people in the outpatient were selected as control group. The colorimetry was used to detect AP, vertebral artery peak was determined by color Doppler ultrasonic imaging instrument. Results The positive rate of AP （93.6%, 96.3%, 90.9%） and vertebral artery peak extension （94.5%, 90.9%, 98.1%） in ischemic cerebrovascular disease group, infarction group and TIA group were higher than those in control group （55.0%, 35.0%）, the differences were statistically significant （P 〈 0.01）, but those in infarction group and TIA group were compared, the differences were not statistically significant （P 〉 0.05）. AP and vertebral artery peak in ischemic cerebrovascular disease group were （6.54±1.88） U and （0.163±0.013） s, compared with control group [（5.82±1.03） U, （0.148±0.016） s], the differences were statistically significant （P 〈 0.05）. Conclusion lschemic cerebrovascular disease is associated with AP and vertebral artery peak.

关 键 词：缺血性脑血管病 溶血磷脂酸 总磷脂 椎动脉 短暂性脑缺血发作 

分 类 号：R743.3[医药卫生—神经病学与精神病学]