ESR1和ESR2基因遗传变异与妇女产后抑郁症的关联性  

Correlation between ESR1 and ESR2 genetic variations and maternal postpartum depression

作　　者：张秋莲[1] 陈从英[2] 龚水萍 黄淑晖[4] 

机构地区：[1]江西农业大学医院妇产科,江西南昌330045 [2]江西农业大学重点实验室 [3]南昌市第二人民医院妇产科 [4]江西省妇幼保健院产科

出　　处：《中国妇幼保健》2014年第28期4634-4637,共4页Maternal and Child Health Care of China

基　　金：江西省自然科学基金〔20114BAB205095〕

摘　　要：目的:研究雌激素受体基因ESR1和ESR2与产后抑郁症发病的相关性。方法:收集113例产后抑郁产妇的血液并建立了数据库,对雌激素受体基因ESR1和ESR2进行SNP搜寻并与产后抑郁症表型做关联性分析。结果:在ESR1基因第1外显子上发现了SNP rs2077647,在ESR2基因第6外显子上发现了SNP rs1256049,并在113例产妇中对这两个SNP进行基因型判定。用R软件进行关联性分析,ESR1基因与产后抑郁症无明显相关性(P=0.115),ESR2基因与产后抑郁症亦无明显相关性(P=0.152)。结论:ESR1基因和ESR2基因可能都不是引起产后抑郁症的主效基因。Objective： To research the correlation between estrogen receptors genes （ESR1 and ESR2 ） and maternal postpartum depression. Methods： Blood samples of 113 women with postpartum depression were collected, and then the database was established; sin- gle nucleotide polymorphisms （SNPs） of ESR1 and ESR2 genes were searched, the relationships with phenotype of postpartum depression were analyzed. Results： SNP rs2077647 was found in the first exon of ESRI gene, SNP rs1256049 was found in the sixth exon of ESR2 gene, genotype determination of these two SNPs was performed. R software was used for correlation analysis, there was no significant correla- tion between ESR1 gene, ESR2 gene and postpartum depression （P =0. 115, P =0. 152） . Conclusion： ESRI gene and ESR2 gene are not maior causal genes of postpartum depression probably.

关 键 词：产后抑郁症 雌激素受体基因 单核苷酸多态性 关联性分析 

分 类 号：R749.2[医药卫生—神经病学与精神病学]